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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0039194,
umls-concept:C0185117,
umls-concept:C1155046,
umls-concept:C1167395,
umls-concept:C1413212,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C2698651,
umls-concept:C2911684
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pubmed:issue |
8
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pubmed:dateCreated |
2004-10-19
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pubmed:abstractText |
It is well established that T lymphocytes undergo homeostatic proliferation in lymphopenic environment. The homeostatic proliferation requires recognition of the major histocompatibility complex on the host. Recent studies have demonstrated that costimulation-mediated CD28, 4-1BB, and CD40 is not required for T cell homeostatic proliferation. It has been suggested that homeostatic proliferation is costimulation independent. Here, we report that T cells from mice with a targeted mutation of CD24 have a remarkably reduced rate of proliferation when adoptively transferred into syngeneic lymphopenic hosts. The reduced proliferation cannot be attributed to abnormal survival and homing properties of the CD24-deficient T cells. T cell proliferation in allogeneic hosts is less affected by this mutation. These results demonstrate a novel function of CD24 expressed on T cells. Thus, although distinct costimulatory molecules are involved in antigen-driven proliferation and homeostatic proliferation, both processes can be modulated by costimulatory molecules.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-10077622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-10485652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-10485653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-10791997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-10952724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-10952725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-10952731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-11172019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-11207270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-11698438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-11807005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-12530982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-12933569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-1346270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-1831224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-2147950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-2435787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-6423764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-7774619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-7908303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-8125140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-8386518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-8609384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-9016874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-9028339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-9368605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-9529332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15477346-9733817
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
200
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1083-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15477346-Adoptive Transfer,
pubmed-meshheading:15477346-Animals,
pubmed-meshheading:15477346-Antigens, CD,
pubmed-meshheading:15477346-Antigens, CD24,
pubmed-meshheading:15477346-Interferon-gamma,
pubmed-meshheading:15477346-L-Selectin,
pubmed-meshheading:15477346-Lymphocyte Activation,
pubmed-meshheading:15477346-Lymphopenia,
pubmed-meshheading:15477346-Membrane Glycoproteins,
pubmed-meshheading:15477346-Mice,
pubmed-meshheading:15477346-Mice, Inbred BALB C,
pubmed-meshheading:15477346-Mice, Inbred C57BL,
pubmed-meshheading:15477346-T-Lymphocytes
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pubmed:year |
2004
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pubmed:articleTitle |
CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host.
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pubmed:affiliation |
Division of Cancer Immunology, Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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