Linked Life Data

15477174

Source:http://linkedlifedata.com/resource/pubmed/id/15477174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-10-12
pubmed:abstractText
While measurements of lung tissue mechanics have been made in several species, relatively little has been reported in the mouse. Moreover, whether in vivo measurements truly reflect tissue properties is somewhat controversial. We measured complex impedance of the mouse respiratory system in vivo using a ventilator, which applies a multiple frequency volume signal to the airway opening. A constant phase model was fit to the impedance data, yielding parameters for tissue damping (G) and elastance (H). Hysteresivity (eta) was calculated as G/H. Quasistatic pressure-volume (P-V) curves were obtained during deflation. In vitro measurements of complex impedance and stress-strain curves were made in lung tissue strips. Values of eta were significantly higher in vivo than in vitro (0.111 +/- 0.004 versus 0.042 +/- 0.003). The higher values of eta in vivo may represent the effects of airway heterogeneities, surfactant, or changes in alveolar geometry. Measurement of mechanics in the tissue strip offers a better assessment of pure tissue properties.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1569-9048
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
143
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-86
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Mechanical properties of mouse distal lung: in vivo versus in vitro comparison.
pubmed:affiliation
Meakins Christie Laboratories, McGill University, 3626 St. Urbain Street, Montreal, Que., Canada H2X 2P2.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't