Source:http://linkedlifedata.com/resource/pubmed/id/15477128
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2004-10-12
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| pubmed:abstractText |
NT-pro-brain natriuretic peptide (NT-proBNP) values are correlated with right ventricle dysfunction in pulmonary hypertension and have been recommended as a prognostic marker for symptomatic primary pulmonary hypertension. The purpose of this pilot study was to determine whether NT-proBNP values correlate with mild to moderate pulmonary hypertension in Gaucher disease. The NT-proBNP assay was performed on sera from patients with type I (non-neuronopathic) Gaucher disease who were known to have tricuspid insufficiency (TI) gradient values on echocardiography that were normal (TI<20 mmHg), borderline (TI=25-29 mmHg), or abnormal (TI>or= 30 mmHg) over time. There was a statistically significant correlation (p=0.05) between mean NT-proBNP values and TI gradient group: mean NT-proBNP for normal TI gradient (n=20 patients)=133.3 (range: 46-445)pg/ml; mean NT-proBNP for borderline TI gradient (n=17 patients)=288.7 (range: 81-1088)pg/ml; and mean NT-proBNP for elevated TI gradient (n=10 patients)=1034.2 (73-6703)pg/ml. Treatment status was not correlated with TI gradient or NT-proBNP values. Thus, in this pilot study of Gaucher disease that included patients with mild to moderate pulmonary hypertension, NT-proBNP was correlated with echocardiographic findings. Further studies will be required to ascertain if NT-proBNP can be used for diagnosis and monitoring of these patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1094-5539
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
17
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
319-23
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15477128-Adolescent,
pubmed-meshheading:15477128-Adult,
pubmed-meshheading:15477128-Aged,
pubmed-meshheading:15477128-Aged, 80 and over,
pubmed-meshheading:15477128-Biological Markers,
pubmed-meshheading:15477128-Child,
pubmed-meshheading:15477128-Child, Preschool,
pubmed-meshheading:15477128-Cohort Studies,
pubmed-meshheading:15477128-Echocardiography,
pubmed-meshheading:15477128-Female,
pubmed-meshheading:15477128-Gaucher Disease,
pubmed-meshheading:15477128-Humans,
pubmed-meshheading:15477128-Hypertension, Pulmonary,
pubmed-meshheading:15477128-Male,
pubmed-meshheading:15477128-Middle Aged,
pubmed-meshheading:15477128-Natriuretic Peptide, Brain,
pubmed-meshheading:15477128-Pilot Projects,
pubmed-meshheading:15477128-Prognosis,
pubmed-meshheading:15477128-Sensitivity and Specificity,
pubmed-meshheading:15477128-Severity of Illness Index,
pubmed-meshheading:15477128-Tricuspid Valve Insufficiency
|
| pubmed:year |
2004
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| pubmed:articleTitle |
N-brain natriuretic peptide: correlation with tricuspid insufficiency in Gaucher disease.
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| pubmed:affiliation |
Gaucher Clinic, Shaare Zedek Medical Center, PO Box 3235, 91031 Jerusalem, Israel.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|