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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-10-12
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pubmed:abstractText |
Cardiac allograft vasculopathy (CAV), a disorder characterized by rapid development and progression of obliterative vasculopathy in the transplanted heart, continues to be a major cause of graft failure in long-surviving human transplants. The mechanisms and histopathologic processes of CAV remain unknown. Previous animal studies have shown that inhibition of matrix metalloproteinase (MMP) prevents migration and proliferation of smooth muscle cells in CAV. In this study, we hypothesized that MMPs may be expressed in and may play an important role in CAV.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1053-2498
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1163-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15477110-Animals,
pubmed-meshheading:15477110-Coronary Disease,
pubmed-meshheading:15477110-Coronary Vessels,
pubmed-meshheading:15477110-Heart Transplantation,
pubmed-meshheading:15477110-Humans,
pubmed-meshheading:15477110-Immunosuppressive Agents,
pubmed-meshheading:15477110-Male,
pubmed-meshheading:15477110-Matrix Metalloproteinase 2,
pubmed-meshheading:15477110-Matrix Metalloproteinases,
pubmed-meshheading:15477110-Phenyl Ethers,
pubmed-meshheading:15477110-Postoperative Complications,
pubmed-meshheading:15477110-Rats,
pubmed-meshheading:15477110-Rats, Inbred F344,
pubmed-meshheading:15477110-Rats, Inbred Strains,
pubmed-meshheading:15477110-Tacrolimus,
pubmed-meshheading:15477110-Tissue Inhibitor of Metalloproteinase-2,
pubmed-meshheading:15477110-Transplantation, Homologous
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pubmed:year |
2004
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pubmed:articleTitle |
ONO-4817, a novel matrix metalloproteinase inhibitor, attenuates allograft vasculopathy in a rat cardiac transplant.
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pubmed:affiliation |
Department of Thoracic and Cardiovascular Surgery, Juntendo University School of Medicine, Tokyo, Japan. ahariya@toranomon.gr.jp
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pubmed:publicationType |
Journal Article
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