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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0005955,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0035696,
umls-concept:C0040184,
umls-concept:C0087140,
umls-concept:C0205267,
umls-concept:C0441472,
umls-concept:C0442805,
umls-concept:C0887949,
umls-concept:C1956225
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pubmed:issue |
11
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pubmed:dateCreated |
2004-10-12
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pubmed:abstractText |
We analyzed the effect of unloading by tail suspension on the anabolic action of intermittent PTH in the tibia of growing mice. Unloading alleviated the PTH-induced increase of bone formation and accelerated bone resorption, consequently reducing bone mass. Reduction of the PTH-induced anabolic actions on bone was associated with unloading, which was apparently related to suppression of c-fos mRNA expression in bone marrow.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/osterix protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1813-20
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15476581-Alkaline Phosphatase,
pubmed-meshheading:15476581-Animals,
pubmed-meshheading:15476581-Body Weight,
pubmed-meshheading:15476581-Bone Marrow Cells,
pubmed-meshheading:15476581-Bone and Bones,
pubmed-meshheading:15476581-Carrier Proteins,
pubmed-meshheading:15476581-Cell Differentiation,
pubmed-meshheading:15476581-DNA, Complementary,
pubmed-meshheading:15476581-DNA Primers,
pubmed-meshheading:15476581-Male,
pubmed-meshheading:15476581-Membrane Glycoproteins,
pubmed-meshheading:15476581-Mice,
pubmed-meshheading:15476581-Mice, Inbred C57BL,
pubmed-meshheading:15476581-Osteoblasts,
pubmed-meshheading:15476581-Osteocalcin,
pubmed-meshheading:15476581-Parathyroid Hormone,
pubmed-meshheading:15476581-Peptide Fragments,
pubmed-meshheading:15476581-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:15476581-RANK Ligand,
pubmed-meshheading:15476581-RNA,
pubmed-meshheading:15476581-RNA, Messenger,
pubmed-meshheading:15476581-Receptor Activator of Nuclear Factor-kappa B,
pubmed-meshheading:15476581-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15476581-Stem Cells,
pubmed-meshheading:15476581-Tibia,
pubmed-meshheading:15476581-Time Factors,
pubmed-meshheading:15476581-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Skeletal unloading alleviates the anabolic action of intermittent PTH(1-34) in mouse tibia in association with inhibition of PTH-induced increase in c-fos mRNA in bone marrow cells.
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pubmed:affiliation |
Department of Orthopedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. tnk-sny@med.uoeh-u.ac.jp
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pubmed:publicationType |
Journal Article
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