Source:http://linkedlifedata.com/resource/pubmed/id/15476480
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2004-10-12
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| pubmed:abstractText |
Influenza vaccination has reduced life-threatening complications from influenza virus infection in adult liver transplant recipients. We evaluated changes in aminotransferase level and immunogenicity of influenza vaccination in liver transplant recipients. Fifty-one liver transplant recipients were administered a standard dose of the 2002-2003 inactivated trivalent influenza vaccine. ALT values were measured at baseline, 1 week and 4-6 weeks postvaccination. Antibody responses to each component of the vaccine were measured at baseline and after 4-6 weeks by a hemagglutination inhibition (HAI) assay. Response was defined as an HAI titer > or = 1: 40 and/or a 4-fold increase in antibody titers from baseline. An ALT elevation was defined as a rise of > or = 50% from baseline. There was no difference in the median rise in ALT value between seroconverters and nonseroconverters. A significant number of recipients developed potentially protective antibody titers (p-value < 0.0001). At less than 4 months post transplantation, 1/7 (14%), at 4-12 months, 6/9 (67%), and after 12 months, 30/35 (86%) subjects responded to the H1 strain. Of 51 recipients, one HCV (-) recipients vaccinated within 3 months of transplantation developed acute cellular rejection. Influenza virus vaccination is not associated with allograft rejection or ALT flares in liver transplant recipients.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Influenza Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1600-6135
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
4
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1805-9
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15476480-Adult,
pubmed-meshheading:15476480-Aged,
pubmed-meshheading:15476480-Alanine Transaminase,
pubmed-meshheading:15476480-Albuminuria,
pubmed-meshheading:15476480-Alkaline Phosphatase,
pubmed-meshheading:15476480-Drug Therapy, Combination,
pubmed-meshheading:15476480-Female,
pubmed-meshheading:15476480-Fever,
pubmed-meshheading:15476480-Hemagglutination Inhibition Tests,
pubmed-meshheading:15476480-Hepatitis C,
pubmed-meshheading:15476480-Humans,
pubmed-meshheading:15476480-Immunosuppressive Agents,
pubmed-meshheading:15476480-Influenza Vaccines,
pubmed-meshheading:15476480-Liver Function Tests,
pubmed-meshheading:15476480-Liver Transplantation,
pubmed-meshheading:15476480-Male,
pubmed-meshheading:15476480-Middle Aged,
pubmed-meshheading:15476480-Serum Albumin
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| pubmed:year |
2004
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| pubmed:articleTitle |
Influenza vaccination in orthotopic liver transplant recipients: absence of post administration ALT elevation.
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| pubmed:affiliation |
Department of Medicine and Division of Liver Diseases, The Mount Sinai Medical Center, New York, NY, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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