Source:http://linkedlifedata.com/resource/pubmed/id/15476451
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2004-10-12
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pubmed:abstractText |
Proinflammatory cytokines are involved in the pathogenesis of non-thyroidal illness (NTI), as shown by studies with IL-6-/- and IL-12-/- mice. Interleukin (IL)-6 changes peripheral thyroid hormone metabolism, and IL-12 seems to be involved in the regulation of the central part of the hypothalamic-pituitary-thyroid (HPT) axis during illness. IL-18 is a proinflammatory cytokine which shares important biological properties with IL-12, such as interferon (IFN)-gamma-inducing activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0804-4643
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
151
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
497-502
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15476451-Animals,
pubmed-meshheading:15476451-Hypothalamo-Hypophyseal System,
pubmed-meshheading:15476451-Inflammation,
pubmed-meshheading:15476451-Interleukin-18,
pubmed-meshheading:15476451-Lipopolysaccharides,
pubmed-meshheading:15476451-Mice,
pubmed-meshheading:15476451-Mice, Inbred C57BL,
pubmed-meshheading:15476451-Mice, Mutant Strains,
pubmed-meshheading:15476451-Pituitary Gland,
pubmed-meshheading:15476451-Receptors, Interferon,
pubmed-meshheading:15476451-Thyroid Gland
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pubmed:year |
2004
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pubmed:articleTitle |
Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis.
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pubmed:affiliation |
Department of Endocrinology, Academic Medical Center, University of Amsterdam, The Netherlands. a.boelen@amc.uva.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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