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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-10-18
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pubmed:abstractText |
Systemic lupus erythematosus (SLE) is characterized by the existence of a heterogeneous group of autoantibodies directed against intact nuclear structures, such as nucleosomes. The most prominent of these autoantibodies are those directed against double-stranded DNA (dsDNA) and histones. The majority are of the IgG isotype and show affinity maturation, both of which are known hallmarks of T cell help. Much evidence suggests that the nucleosome is a major candidate autoantigen in SLE. In this study, a novel strategy was used to identify the critical CD4+ T cell autoepitopes in nucleosomes. In addition, peptide-based therapy was then performed in a lupus animal model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 American College of Rheumatology
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3250-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15476240-Animals,
pubmed-meshheading:15476240-Autoantigens,
pubmed-meshheading:15476240-Bone Marrow,
pubmed-meshheading:15476240-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15476240-DNA,
pubmed-meshheading:15476240-Dendritic Cells,
pubmed-meshheading:15476240-Disease Models, Animal,
pubmed-meshheading:15476240-Epitopes, T-Lymphocyte,
pubmed-meshheading:15476240-Histones,
pubmed-meshheading:15476240-Immunotherapy,
pubmed-meshheading:15476240-Lupus Erythematosus, Systemic,
pubmed-meshheading:15476240-Mice,
pubmed-meshheading:15476240-Mice, Inbred Strains,
pubmed-meshheading:15476240-Nucleosomes
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pubmed:year |
2004
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pubmed:articleTitle |
Treatment of murine lupus using nucleosomal T cell epitopes identified by bone marrow-derived dendritic cells.
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pubmed:affiliation |
Kaoshiung Medical University, Kaoshiung, Taiwan, Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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