rdf:type |
|
lifeskim:mentions |
umls-concept:C0021753,
umls-concept:C0030685,
umls-concept:C0030705,
umls-concept:C0039082,
umls-concept:C0205191,
umls-concept:C0205494,
umls-concept:C0221912,
umls-concept:C0231330,
umls-concept:C0383327,
umls-concept:C0391871,
umls-concept:C0521339,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1963578,
umls-concept:C2349975
|
pubmed:issue |
10
|
pubmed:dateCreated |
2004-10-18
|
pubmed:abstractText |
Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome is a severe inflammatory disease that recently was associated with mutations in CIAS1. It was hypothesized that these mutations may lead to enhanced inflammatory responses. Herein, we provide evidence that inflammation in the CINCA syndrome is characterized by enhanced interleukin-1beta (IL-1beta) and IL-18 release upon stimulation of blood cells and show that this release is caspase 1 dependent.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0004-3591
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright 2004 American College of Rheumatology
|
pubmed:issnType |
Print
|
pubmed:volume |
50
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
3329-33
|
pubmed:dateRevised |
2007-7-24
|
pubmed:meshHeading |
pubmed-meshheading:15476236-Blood Cells,
pubmed-meshheading:15476236-Carrier Proteins,
pubmed-meshheading:15476236-Caspase 1,
pubmed-meshheading:15476236-Child,
pubmed-meshheading:15476236-Chronic Disease,
pubmed-meshheading:15476236-Female,
pubmed-meshheading:15476236-Humans,
pubmed-meshheading:15476236-Interleukin-1,
pubmed-meshheading:15476236-Interleukin-18,
pubmed-meshheading:15476236-Joint Diseases,
pubmed-meshheading:15476236-Mutation,
pubmed-meshheading:15476236-Nervous System Diseases,
pubmed-meshheading:15476236-Skin Diseases,
pubmed-meshheading:15476236-Syndrome
|
pubmed:year |
2004
|
pubmed:articleTitle |
Enhanced interleukin-1beta and interleukin-18 release in a patient with chronic infantile neurologic, cutaneous, articular syndrome.
|
pubmed:affiliation |
Leiden University Medical Center, Leiden, The Netherlands.
|
pubmed:publicationType |
Journal Article,
Case Reports
|