rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-10-18
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pubmed:abstractText |
The main genetic risk factor for rheumatoid arthritis (RA) is the shared epitope (SE) of HLA-DR, while smoking is an important environmental risk factor. We studied a potential gene-environment interaction between SE genes and smoking in the etiology of the 2 major subgroups of RA: rheumatoid factor (RF)-seropositive and RF-seronegative disease.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 American College of Rheumatology
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3085-92
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15476204-Adolescent,
pubmed-meshheading:15476204-Adult,
pubmed-meshheading:15476204-Aged,
pubmed-meshheading:15476204-Arthritis, Rheumatoid,
pubmed-meshheading:15476204-Case-Control Studies,
pubmed-meshheading:15476204-Epitopes,
pubmed-meshheading:15476204-Female,
pubmed-meshheading:15476204-Genetic Predisposition to Disease,
pubmed-meshheading:15476204-HLA-DR Antigens,
pubmed-meshheading:15476204-HLA-DRB1 Chains,
pubmed-meshheading:15476204-Humans,
pubmed-meshheading:15476204-Male,
pubmed-meshheading:15476204-Middle Aged,
pubmed-meshheading:15476204-Rheumatoid Factor,
pubmed-meshheading:15476204-Risk Factors,
pubmed-meshheading:15476204-Smoking
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pubmed:year |
2004
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pubmed:articleTitle |
A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis.
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pubmed:affiliation |
Karolinska Institutet, Stockholm, Sweden, and Mechnikov Research Institute, Stockholm, Sweden. leonid.padyukov@cmm.ki.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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