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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2004-10-11
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pubmed:abstractText |
CD74 (HLA-DR-associated invariant chain) plays a role in antigen presentation. In addition to its expression on antigen-presenting cells, it is expressed by carcinomas of renal, lung, gastric, and thymic origin and by certain sarcomas. The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases. Preclinical efficacy of anti-CD74 monoclonal antibody (mAb) therapy has been demonstrated in B-lymphoma models. Because there are few validated antigenic targets in multiple myeloma, CD74 expression was examined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6606-11
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15475450-Animals,
pubmed-meshheading:15475450-Antibodies, Monoclonal,
pubmed-meshheading:15475450-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:15475450-Cell Line, Tumor,
pubmed-meshheading:15475450-Cell Proliferation,
pubmed-meshheading:15475450-Flow Cytometry,
pubmed-meshheading:15475450-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15475450-Histocompatibility Antigens Class II,
pubmed-meshheading:15475450-Humans,
pubmed-meshheading:15475450-Immunohistochemistry,
pubmed-meshheading:15475450-Lymphoma, B-Cell,
pubmed-meshheading:15475450-Mice,
pubmed-meshheading:15475450-Multiple Myeloma,
pubmed-meshheading:15475450-Plasma Cells,
pubmed-meshheading:15475450-RNA, Messenger,
pubmed-meshheading:15475450-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15475450-Thymidine,
pubmed-meshheading:15475450-Tritium
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pubmed:year |
2004
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pubmed:articleTitle |
CD74 is expressed by multiple myeloma and is a promising target for therapy.
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pubmed:affiliation |
Center for Molecular Medicine and Immunology and Garden State Cancer Center, Belleville, New Jersey 07109, USA. jburton@gscancer.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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