|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2004-10-11
|
|
pubmed:abstractText |
Knockout of the translation inhibitor 4E-BP1 induces an overexpression of uncoupling protein-1 (UCP1) [Nature Medicine 7 (2001) 1128]. A possible inverse control of UCP1 and 4E-BP1 expressions in mouse brown adipose tissue was investigated. Cold-exposure, which increases the expression of UCP1, decreased that of 4E-BP1 mRNA in wild type but not in beta1/beta2/beta3-adrenoceptor knockout mice. Administration of the beta3-adrenoceptor agonist CL 316246 decreased 4E-BP1 mRNA by 75% and protein by 41% after 6 and 48 h, respectively. Our data are the first report of a regulation by the beta3-adrenoceptor of 4E-BP1 expression. They support a role of the latter in adaptive thermogenesis.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2004 Federation of European Biochemical Societies
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
8
|
|
pubmed:volume |
576
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
179-82
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:15474034-Adipose Tissue, Brown,
pubmed-meshheading:15474034-Adrenergic beta-Agonists,
pubmed-meshheading:15474034-Animals,
pubmed-meshheading:15474034-Blotting, Western,
pubmed-meshheading:15474034-Cold Temperature,
pubmed-meshheading:15474034-Eukaryotic Initiation Factors,
pubmed-meshheading:15474034-Female,
pubmed-meshheading:15474034-Gene Expression Regulation,
pubmed-meshheading:15474034-Mice,
pubmed-meshheading:15474034-Mice, Inbred C57BL,
pubmed-meshheading:15474034-Mice, Knockout,
pubmed-meshheading:15474034-RNA, Messenger,
pubmed-meshheading:15474034-Receptors, Adrenergic, beta-3,
pubmed-meshheading:15474034-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15474034-Time Factors
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptor.
|
|
pubmed:affiliation |
Department of Cell Physiology and Metabolism, Centre Médical Universitaire, 1, rue Michel-Servet, 1211 Geneva 4, Switzerland. lehr6@etu.unige.ch
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
