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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2004-12-3
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pubmed:abstractText |
Atherosclerosis is a disease marked by lipid accumulation and inflammation. Recently, atherosclerosis has gained recognition as an autoimmune-type syndrome characterized by increased activation of the innate and acquired immune systems. Natural killer T (NKT) cells have characteristics of both conventional T cells and NK cells and recognize glycolipid antigens presented in association with CD1d molecules on antigen-presenting cells. The capacity of NKT cells to respond to lipid antigens and modulate innate and acquired immunity suggests that they may play a role in atherogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2351-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15472130-Age Factors,
pubmed-meshheading:15472130-Animals,
pubmed-meshheading:15472130-Antigens, CD1,
pubmed-meshheading:15472130-Aorta,
pubmed-meshheading:15472130-Apolipoproteins E,
pubmed-meshheading:15472130-Arteriosclerosis,
pubmed-meshheading:15472130-Cytokines,
pubmed-meshheading:15472130-Galactosylceramides,
pubmed-meshheading:15472130-Killer Cells, Natural,
pubmed-meshheading:15472130-Lymphocyte Activation,
pubmed-meshheading:15472130-Lymphocyte Subsets,
pubmed-meshheading:15472130-Male,
pubmed-meshheading:15472130-Mice,
pubmed-meshheading:15472130-Mice, Inbred C57BL,
pubmed-meshheading:15472130-Phenotype,
pubmed-meshheading:15472130-Qualitative Research
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pubmed:year |
2004
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pubmed:articleTitle |
Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice.
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pubmed:affiliation |
Department of Medicine, Division of Cardiovascular Medicine, 2220 Pierce Avenue, Room 383 PRB, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. amy.major@vanderbilt.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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