pubmed-article:15471558 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:15471558 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
pubmed-article:15471558 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
pubmed-article:15471558 | lifeskim:mentions | umls-concept:C2699153 | lld:lifeskim |
pubmed-article:15471558 | lifeskim:mentions | umls-concept:C1269955 | lld:lifeskim |
pubmed-article:15471558 | lifeskim:mentions | umls-concept:C1420361 | lld:lifeskim |
pubmed-article:15471558 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
pubmed-article:15471558 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
pubmed-article:15471558 | pubmed:issue | 9 | lld:pubmed |
pubmed-article:15471558 | pubmed:dateCreated | 2004-10-8 | lld:pubmed |
pubmed-article:15471558 | pubmed:abstractText | We have previously demonstrated significantly decreased immunoreactivity of hepatocyte growth factor activator inhibitor type 1 (HAI-1), an integral membrane protein that exhibits potent inhibitory activity against hepatocyte growth factor activator (HGFA) and matriptase, in colorectal adenocarcinomas. In this report, we describe further detailed analysis of HAI-1 expression in colorectal adenocarcinoma by using three kinds of anti-HAI-1 antibodies, each of which recognizes a distinct epitope of the HAI-1 molecule, and also by in-situ hybridization for HAI-1 mRNA. The results indicated that the decreased immunoreactivity of HAI-1 in colorectal carcinoma cells is largely a result of enhanced ectodomain shedding of HAI-1 in these cells. In contrast, immunoreactivity of mature membrane-form HAI-1 was paradoxically en-hanced in cancer cells at the invasion front, showing intense cell-stroma interactions and/or sprouting invasion. This finding indicates that these invading cells showed decreased ectodomain shedding of HAI-1 and consequently might require the existence of the membrane-form HAI-1. Of particular interest was the observation of a possible inverse correlation between paradoxical up-regulation of membrane-form HAI-1 expression and membrane-associated E-cadherin in these cells. These membrane-form HAI-1-positive sprouting cancer cells were also negative for MIB-1 immunohistochemically, indicating a low-proliferating population. All these results suggest that HAI-1 may mediate diverse functions in regard to the progression of colorectal carcinomas, and the immunoreactivity of membrane-form HAI-1 may serve as a marker of invading cancer cells. | lld:pubmed |
pubmed-article:15471558 | pubmed:language | eng | lld:pubmed |
pubmed-article:15471558 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15471558 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:15471558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15471558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15471558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15471558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15471558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15471558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15471558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15471558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15471558 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:15471558 | pubmed:month | Sep | lld:pubmed |
pubmed-article:15471558 | pubmed:issn | 1347-9032 | lld:pubmed |
pubmed-article:15471558 | pubmed:author | pubmed-author:ItohHiroshiH | lld:pubmed |
pubmed-article:15471558 | pubmed:author | pubmed-author:TanakaHiroyuk... | lld:pubmed |
pubmed-article:15471558 | pubmed:author | pubmed-author:KataokaHiroak... | lld:pubmed |
pubmed-article:15471558 | pubmed:author | pubmed-author:ChijiiwaKazuo... | lld:pubmed |
pubmed-article:15471558 | pubmed:author | pubmed-author:UchiyamaShuic... | lld:pubmed |
pubmed-article:15471558 | pubmed:author | pubmed-author:NagaikeKokiK | lld:pubmed |
pubmed-article:15471558 | pubmed:author | pubmed-author:KohamaKazuyoK | lld:pubmed |
pubmed-article:15471558 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:15471558 | pubmed:volume | 95 | lld:pubmed |
pubmed-article:15471558 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:15471558 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:15471558 | pubmed:pagination | 728-35 | lld:pubmed |
pubmed-article:15471558 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:meshHeading | pubmed-meshheading:15471558... | lld:pubmed |
pubmed-article:15471558 | pubmed:year | 2004 | lld:pubmed |
pubmed-article:15471558 | pubmed:articleTitle | Paradoxically enhanced immunoreactivity of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in cancer cells at the invasion front. | lld:pubmed |
pubmed-article:15471558 | pubmed:affiliation | Second Department of Pathology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan. | lld:pubmed |
pubmed-article:15471558 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:15471558 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:15471558 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15471558 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15471558 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15471558 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15471558 | lld:pubmed |