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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-10-7
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pubmed:abstractText |
In the treatment of heart failure and hypertension with metoprolol, ultrarapid metabolizers (UMs) may not achieve optimal target concentrations with recommended doses. We compared metoprolol pharmacokinetics and effects in UMs with extensive metabolizers (EMs) and with poor metabolizers (PM) as an additional reference group.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0009-9236
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
302-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15470329-Administration, Oral,
pubmed-meshheading:15470329-Adrenergic beta-Antagonists,
pubmed-meshheading:15470329-Adult,
pubmed-meshheading:15470329-Alleles,
pubmed-meshheading:15470329-Area Under Curve,
pubmed-meshheading:15470329-Blood Pressure,
pubmed-meshheading:15470329-Cytochrome P-450 CYP2D6,
pubmed-meshheading:15470329-Exercise Test,
pubmed-meshheading:15470329-Female,
pubmed-meshheading:15470329-Genotype,
pubmed-meshheading:15470329-Heart Rate,
pubmed-meshheading:15470329-Humans,
pubmed-meshheading:15470329-Male,
pubmed-meshheading:15470329-Metoprolol
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pubmed:year |
2004
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pubmed:articleTitle |
Impact of the ultrarapid metabolizer genotype of cytochrome P450 2D6 on metoprolol pharmacokinetics and pharmacodynamics.
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pubmed:affiliation |
Institute of Clinical Pharmacology, Humboldt University, Berlin, Germany. julia.kirchheiner@uk-koeln.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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