Linked Life Data

15468954

Source:http://linkedlifedata.com/resource/pubmed/id/15468954

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-10-7
pubmed:abstractText
The present study analyzed morphological and immunohistochemical changes of thymic epithelial cells in the irradiated and recovering rat thymus. Observations showed the number of thymocytes was initially severely reduced after irradiation but abruptly increased on days 3 to 5 after 6 Gy and on days 7 to 11 after 8 Gy irradiation. To analyse the mechanisms for this abrupt recovery of the thymocytes after irradiation, the expression of p63 in the normal and irradiated thymus was immunohistochemically studied as the expression of this antigen may be related to the proliferation of epithelial cells. In the fetal thymus tissue, thymic epithelial cells were the principal cell type that stained strongly positive for p63. The sporadic expression of p63 was also observed in the normal adult thymus tissue, especially in the subcapsular region. An increased number of p63- positive cells in the thymus after irradiation indicates that repair or renewal of the thymic epithelial cells may be taking place because p63 is more specific to transient amplifying thymic epithelial cells. A RT-PCR analysis of p63 expression in irradiated and regenerating thymus tissue also showed an increased expression of p63 after irradiation compared with that of the normal thymus. These results suggest that changes in the thymic microenvironment-especially in relation to the repair and renewal of thymic epithelial cells- may have an important influence on thymocyte proliferation in the normal thymus as well as in the irradiated and recovering thymus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0914-9465
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-58
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Morphological and immunohistochemical changes to thymic epithelial cells in the irradiated and recovering rat thymus.
pubmed:affiliation
Department of Human Science, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan. da@yamaguchi-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't