Linked Life Data

15468286

Source:http://linkedlifedata.com/resource/pubmed/id/15468286

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-10-6
pubmed:abstractText
The size distributions of fibroblast growth factor-2 (FGF-2) in aqueous solutions with neutral pH were investigated with a dynamic light scattering technique. We found that the FGF-2 was distributed in dimer or trimer form at concentrations of 0.1-1.0 mg . mL(-1). An aggregate with a hydrodynamic radius of approximately 90 nm coexisted with this and its proportion increased with a decrease in concentration. At lower concentrations (less than 0.10 mg . mL(-1)) FGF-2 aggregates with an average radius of 80-100 nm were dominant and were stable for more than a day. These FGF-2 solutions were mixed with calcium phosphate solutions to produce a sub-micron sized compound of FGF-2 and hydroxyapatite, which could be used as a biological implant that possessed a pharmacological function for bone formation. By utilizing a transformation from amorphous calcium phosphate to hydroxyapatite, FGF-2 was effectively incorporated into polycrystals of hydroxyapatite.SEM photograph of a mixture of hydroxyapatite and FGF-2.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1616-5187
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-46
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Association of calcium phosphate and fibroblast growth factor-2: a dynamic light scattering study.
pubmed:affiliation
Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't