Linked Life Data

15466980

Source:http://linkedlifedata.com/resource/pubmed/id/15466980

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2004-10-6
pubmed:abstractText
Exploring the associations between genetic polymorphisms of metabolic enzymes and susceptibility to polycyclic aromatic hydrocarbon (PAH)-induced chromosomal damage is of great significance for understanding PAH carcinogenesis. Cytochrome P450, glutathione S-transferase, microsomal epoxide hydrolase, NAD(P)H:quinone oxidoreductase, and N-acetyltransferase are PAH-metabolizing enzymes. In this study, we genotyped for the polymorphisms of these genes and assessed their effects on cytokinesis-block micronucleus (CBMN) frequencies in peripheral blood lymphocytes among 141 coke-oven workers and 66 non-coke-oven worker controls. The geometric means of urinary 1-hydroxypyrene levels in coke-oven workers and the controls were 12.0 and 0.7 micromol/mol creatinine, respectively (P < 0.01). The CBMN frequency (number of micronuclei per 1,000 binucleated lymphocytes) was significantly higher in coke-oven workers (9.5 +/- 6.6 per thousand) than in the controls (4.0 +/- 3.6 per thousand; P < 0.01). Among the coke-oven workers, age was positively associated with CBMN frequency; the mEH His113 variant genotype exhibited significantly lower CBMN frequency (8.5 +/- 6.5 per thousand) than did the Tyr113/Tyr113 genotype (11.3 +/- 6.4 per thousand; P < 0.01); the low mEH activity phenotype exhibited a lower CBMN frequency (8.6 +/- 6.8 per thousand) than did the high mEH activity phenotype (13.2 +/- 6.7 per thousand; P = 0.01); the GSTP1 Val105/Val105 genotype exhibited a higher CBMN frequency (15.0 +/- 5.8 per thousand) than did the GSTP1 Ile105/Ile105 or Ile105/Val105 genotypes (9.3 +/- 6.5 per thousand; P < 0.01); the joint effect of high mEH activity phenotype and GSTM1 null genotype on CBMN frequencies was also found. Gene-environment interactions between occupational PAH exposure and polymorphisms of mEH and/or GSTM1 were also evident. These results indicate that the mEH, GSTP1, and GSTM1 polymorphisms may play a role in sensitivity or genetic susceptibility to the genotoxic effects of PAH exposure in the coke-oven workers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1631-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15466980-Acyltransferases, pubmed-meshheading:15466980-Adult, pubmed-meshheading:15466980-Coke, pubmed-meshheading:15466980-Cytokinesis, pubmed-meshheading:15466980-DNA Damage, pubmed-meshheading:15466980-Epoxide Hydrolases, pubmed-meshheading:15466980-Female, pubmed-meshheading:15466980-Genetic Predisposition to Disease, pubmed-meshheading:15466980-Genotype, pubmed-meshheading:15466980-Glutathione Transferase, pubmed-meshheading:15466980-Humans, pubmed-meshheading:15466980-Incineration, pubmed-meshheading:15466980-Lymphocytes, pubmed-meshheading:15466980-Male, pubmed-meshheading:15466980-Micronuclei, Chromosome-Defective, pubmed-meshheading:15466980-Middle Aged, pubmed-meshheading:15466980-Occupational Exposure, pubmed-meshheading:15466980-Polycyclic Hydrocarbons, Aromatic, pubmed-meshheading:15466980-Polymorphism, Genetic
pubmed:year
2004
pubmed:articleTitle
Effects of genetic polymorphisms of metabolic enzymes on cytokinesis-block micronucleus in peripheral blood lymphocyte among coke-oven workers.
pubmed:affiliation
National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing, 100050.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't