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rdf:type |
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lifeskim:mentions |
umls-concept:C0004048,
umls-concept:C0020542,
umls-concept:C0028128,
umls-concept:C0042402,
umls-concept:C0205178,
umls-concept:C0234422,
umls-concept:C0871261,
umls-concept:C1097411,
umls-concept:C1123019,
umls-concept:C1555029,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2709248,
umls-concept:C2911692
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pubmed:issue |
15
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pubmed:dateCreated |
2004-10-12
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pubmed:abstractText |
Inhaled nitric oxide (NO) is a potent and selective pulmonary vasodilator, which induces cGMP synthesis by activating soluble guanylate cyclase (sGC) in ventilated lung regions. Carbon monoxide (CO) has also been proposed to influence smooth muscle tone via activation of sGC. We examined whether direct stimulation of sGC by BAY 41-2272 would produce pulmonary vasodilation and augment the pulmonary responses to inhaled NO or CO.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-Hydroxy-11 alpha,9...,
http://linkedlifedata.com/resource/pubmed/chemical/3-(4-Amino-5-cyclopropylpyrimidine-2...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Dioxide,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Monoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase-Activating...,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2253-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15466650-15-Hydroxy-11 alpha,9...,
pubmed-meshheading:15466650-Administration, Inhalation,
pubmed-meshheading:15466650-Animals,
pubmed-meshheading:15466650-Blood Pressure,
pubmed-meshheading:15466650-Calcium-Binding Proteins,
pubmed-meshheading:15466650-Carbon Dioxide,
pubmed-meshheading:15466650-Carbon Monoxide,
pubmed-meshheading:15466650-Cyclic GMP,
pubmed-meshheading:15466650-Drug Evaluation, Preclinical,
pubmed-meshheading:15466650-Drug Interactions,
pubmed-meshheading:15466650-Guanylate Cyclase-Activating Proteins,
pubmed-meshheading:15466650-Hypertension, Pulmonary,
pubmed-meshheading:15466650-Infusions, Intravenous,
pubmed-meshheading:15466650-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:15466650-Nitric Oxide,
pubmed-meshheading:15466650-Oxygen,
pubmed-meshheading:15466650-Pulmonary Artery,
pubmed-meshheading:15466650-Pyrazoles,
pubmed-meshheading:15466650-Pyridines,
pubmed-meshheading:15466650-Sheep,
pubmed-meshheading:15466650-Vascular Resistance,
pubmed-meshheading:15466650-Vasodilator Agents,
pubmed-meshheading:15466650-Wakefulness
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pubmed:year |
2004
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pubmed:articleTitle |
Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs.
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pubmed:affiliation |
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, CLN 309, Boston, Mass 02114, USA. evgenov@etherdome.mgh.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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