| pubmed-article:15465914 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15465914 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15465914 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15465914 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:15465914 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15465914 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15465914 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15465914 | pubmed:issue | 41 | lld:pubmed |
| pubmed-article:15465914 | pubmed:dateCreated | 2004-10-13 | lld:pubmed |
| pubmed-article:15465914 | pubmed:abstractText | Although there was no impairment in IL-2 secretion and proliferation of Fyn-deficient naïve CD4 cells after stimulation with antigen and antigen-presenting cells, stimulation of these cells with anti-CD3 and anti-CD28 revealed profound defects. Crosslinking of purified wild-type naïve CD4 cells with anti-CD3 activated Lck and initiated the signaling cascade downstream of Lck, including phosphorylation of ZAP-70, LAT, and PLC-gamma1; calcium flux; and dephosphorylation and nuclear translocation of the nuclear factor of activated T cells (NFAT)p. All of these signaling events were diminished severely in Fyn-deficient naïve cells activated by CD3 crosslinking. Coaggregation of CD3 and CD4 reconstituted this Lck-dependent signaling pathway in Fyn(-/-) T cells. These results suggest that when signaling of naïve T cells is restricted to the T cell antigen receptor, Fyn plays an essential role by positive regulation of Lck activity. | lld:pubmed |
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| pubmed-article:15465914 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15465914 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15465914 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15465914 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15465914 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:15465914 | pubmed:author | pubmed-author:GreyHoward... | lld:pubmed |
| pubmed-article:15465914 | pubmed:author | pubmed-author:JeonMyung-Shi... | lld:pubmed |
| pubmed-article:15465914 | pubmed:author | pubmed-author:SugieKatsujiK | lld:pubmed |
| pubmed-article:15465914 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15465914 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:15465914 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:15465914 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15465914 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15465914 | pubmed:pagination | 14859-64 | lld:pubmed |
| pubmed-article:15465914 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15465914 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15465914 | pubmed:articleTitle | Activation of naïve CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling. | lld:pubmed |
| pubmed-article:15465914 | pubmed:affiliation | Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA. | lld:pubmed |
| pubmed-article:15465914 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15465914 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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