Linked Life Data

15465080

Source:http://linkedlifedata.com/resource/pubmed/id/15465080

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2004-10-6
pubmed:abstractText
In recent years it has become clear that multiple sclerosis (MS) patients benefit from physical exercise as performed in aerobic training but little is known about the effect on functional domains and physiological factors mediating these effects. We studied immunological, endocrine and neurotrophic factors as well as coordinative function and quality of life during an 8-week aerobic bicycle training in a waitlist control design. In the immune-endocrine study (1) 28 patients were included, the coordinative extension study (2) included 39 patients. Training was performed at 60% VO(2)max after determining individual exertion levels through step-by-step ergometry. Metabolic (lactate), endocrine (cortisol, adrendocortico-releasing hormone, epinephrine, norepinephrine), immune (IL-6, soluble IL-6 receptor), and neurotrophic (brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF)) parameters were compared from a prestudy and a poststudy endurance test at 60% VO(2)max for 30 min. In study (1), lowered lactate levels despite higher workload levels indicated a training effect. Disease-specific quality of life (as measured by the Hamburg Quality of Life Questionnaire for Multiple Sclerosis, HAQUAMS) significantly increased in the training group. No significant training effects were seen for endocrine and immune parameters or neurotrophins. In study (2), two out of three coordinative parameters of the lower extremities were significantly improved. In summary, low-level aerobic training in MS improves not only quality of life but also coordinative function and physical fitness.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
225
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15465080-Adrenocorticotropic Hormone, pubmed-meshheading:15465080-Adult, pubmed-meshheading:15465080-Affect, pubmed-meshheading:15465080-Analysis of Variance, pubmed-meshheading:15465080-Area Under Curve, pubmed-meshheading:15465080-Carbolines, pubmed-meshheading:15465080-Chromatography, High Pressure Liquid, pubmed-meshheading:15465080-Electrochemistry, pubmed-meshheading:15465080-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:15465080-Epinephrine, pubmed-meshheading:15465080-Exercise, pubmed-meshheading:15465080-Exercise Test, pubmed-meshheading:15465080-Female, pubmed-meshheading:15465080-Humans, pubmed-meshheading:15465080-Immune System, pubmed-meshheading:15465080-Interleukin-6, pubmed-meshheading:15465080-Male, pubmed-meshheading:15465080-Middle Aged, pubmed-meshheading:15465080-Multiple Sclerosis, pubmed-meshheading:15465080-Nerve Growth Factors, pubmed-meshheading:15465080-Neurosecretory Systems, pubmed-meshheading:15465080-Psychomotor Performance, pubmed-meshheading:15465080-Quality of Life, pubmed-meshheading:15465080-Questionnaires, pubmed-meshheading:15465080-Receptors, Interleukin-6
pubmed:year
2004
pubmed:articleTitle
Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis.
pubmed:affiliation
Institute of Medical Psychology and Transplantation-Center, University Hospital Eppendorf, Martinistrasse 52, S3520246 Hamburg, Germany.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, Non-U.S. Gov't