Source:http://linkedlifedata.com/resource/pubmed/id/15464862
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2004-10-6
|
| pubmed:abstractText |
SOD1 is one of several overexpressed genes in Down's syndrome. In order to dissect genetic causes of the syndrome, hemizygous human wild-type SOD1 transgenic mice were compared to FVB/N non-transgenic controls at 3 months of age in the SHIRPA primary screen of neurologic function as well as in tests of motor activity and coordination. The responsiveness of SOD1/wt transgenic mice to visual and somatosensory stimuli was reduced in placing, pinna, corneal, and toe-pinch tests. In addition, SOD1/wt transgenic mice crossed fewer segments on a stationary beam. On the contrary, there was no intergroup difference for motor activity and anxiety in open-field and emergence tests and for latencies before falling on the stationary beam, coat-hanger, and rotorod. These results indicate mild deficits in sensorimotor responsiveness in a mouse model expressing human SOD1 and that the overexpressed gene may be responsible for some Down symptoms.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0361-9230
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
64
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
251-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15464862-Animals,
pubmed-meshheading:15464862-Anxiety Disorders,
pubmed-meshheading:15464862-Disease Models, Animal,
pubmed-meshheading:15464862-Down Syndrome,
pubmed-meshheading:15464862-Exploratory Behavior,
pubmed-meshheading:15464862-Female,
pubmed-meshheading:15464862-Humans,
pubmed-meshheading:15464862-Impulsive Behavior,
pubmed-meshheading:15464862-Male,
pubmed-meshheading:15464862-Mice,
pubmed-meshheading:15464862-Mice, Transgenic,
pubmed-meshheading:15464862-Motor Activity,
pubmed-meshheading:15464862-Movement Disorders,
pubmed-meshheading:15464862-Neurologic Examination,
pubmed-meshheading:15464862-Pain Measurement,
pubmed-meshheading:15464862-Physical Stimulation,
pubmed-meshheading:15464862-Somatosensory Disorders,
pubmed-meshheading:15464862-Superoxide Dismutase
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Characterization of hemizygous SOD1/wild-type transgenic mice with the SHIRPA primary screen and tests of sensorimotor function and anxiety.
|
| pubmed:affiliation |
Faculté de Médecine et de Pharmacie, Université de Rouen, INSERM U614, Bâtiment de Recherche, 22 bld Gambetta, Salle 1D18, 76183 Rouen, Cedex, France. robert.lalonde@univ-rouen.fr
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|