|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2004-10-6
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Recently, the gene called DAAO was reported to be associated with schizophrenia in the French Canadian populations. Here, we report a result obtained in the study of our large collection of 547 schizophrenia cases and 536 controls in the Chinese population. Six single-nucleotide polymorphisms (SNPs) were genotyped at and around the DAAO locus, covering a 10-kb region entirely encompassing the complementary DNA sequences of DAAO. We found statistically significant differences in allele distributions on one marker: SNP rs3741775 (P = 0.0000001). In the haplotype analysis based on the information of linkage-disequilibrium block across this gene locus, we demonstrated a highly significant association between schizophrenia and a DAAO haplotype (P = 2.0173 x 10(-21)), which therefore provides an independent statistical support for association of the DAAO gene with schizophrenia and indicates that the DAAO gene may play a significant role in the etiology of schizophrenia in the Han Chinese.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0304-3940
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
21
|
|
pubmed:volume |
369
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
228-33
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15464270-Alleles,
pubmed-meshheading:15464270-Asian Continental Ancestry Group,
pubmed-meshheading:15464270-Case-Control Studies,
pubmed-meshheading:15464270-Cohort Studies,
pubmed-meshheading:15464270-D-Amino-Acid Oxidase,
pubmed-meshheading:15464270-Female,
pubmed-meshheading:15464270-Gene Frequency,
pubmed-meshheading:15464270-Genetic Predisposition to Disease,
pubmed-meshheading:15464270-Haplotypes,
pubmed-meshheading:15464270-Humans,
pubmed-meshheading:15464270-Linkage Disequilibrium,
pubmed-meshheading:15464270-Male,
pubmed-meshheading:15464270-Odds Ratio,
pubmed-meshheading:15464270-Polymorphism, Single Nucleotide,
pubmed-meshheading:15464270-RNA, Messenger,
pubmed-meshheading:15464270-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15464270-Schizophrenia
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Association of DAAO with schizophrenia in the Chinese population.
|
|
pubmed:affiliation |
Bio-X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, 1954 Huashan Road, P.O. Box 501, Shanghai 200030, PR China.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
