Source:http://linkedlifedata.com/resource/pubmed/id/15463628
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2004-10-6
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| pubmed:abstractText |
The mechanisms for several important features o f African trypanosomiasis are still largely unexplained. These include (1) the occurrence of parasite growth-promoting molecules provided by the host, (2) polyclonal T- and B-cell activation and the development of immunosuppression and (3) neuropsychiatric signs. Here Tomas Olsson, Moiz Bakhiet and Krister Kristensson focus on interactive events between Trypanosoma brucei and CD8(+) T cells, and the release of a diffusible molecule from T. brucei that triggers CD8(+) T cells to produce interferon-gamma (IFN-gamma). This cytokine provides a growth stimulus for the parasite and modulates events in the host's immune and nervous systems.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0169-4758
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
237-9
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| pubmed:year |
1992
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| pubmed:articleTitle |
Interactions between Trypanosoma brucei and CD8+ T cells.
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| pubmed:affiliation |
Department of Neurology, Karolinska Institute, Huddinge University Hospital, S-141 86 Huddinge, Stockholm, Sweden.
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| pubmed:publicationType |
Journal Article
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