Linked Life Data

15462745

Source:http://linkedlifedata.com/resource/pubmed/id/15462745

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-10-6
pubmed:abstractText
When malaria parasites enter red blood cells they precipitate on influx of substrates necessary for their development. For example, intraerythrocytic trophozoites of Plasmodium falciparum use exogenous t-glutamine in increasing amounts during maturation from the ring-stage. This is made possible by a marked and selective increase in the permeability of the host cell membrane. Several compounds have now been identified as inhibitors of the l-glutamine influx induced by P. falciparum; they are all natural products - either analogues of l-glutamine, or related to indigenous traditional remedies for malaria. In this article, Barry El ford shows that although these compounds may not be of immediate practical value as antimolarials, they can provide valuable insight into the mechanisms underlying the regulation of these parasite-mediated transport processes.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Nov
pubmed:issn
0169-4758
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
309-12
pubmed:year
1986
pubmed:articleTitle
L-Glutamine influx in malaria-infected erythrocytes: a target for antimalarials?
pubmed:affiliation
Clinical Research Centre, WatfordRoad, Harrow HA1 3UJ, UK.
pubmed:publicationType
Journal Article