|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2004-10-6
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|
pubmed:abstractText |
Considerable variability in sensitivity to corticosteroids (CS) has been observed among individuals with regard to both the natural and synthetic compounds. The role of genetic polymorphisms in modulating CS function, and hence in disease susceptibility, has been extensively analyzed. Their impact on therapeutic response still remains to be explored. The role of cytochrome P450 (CYP) 3A4 in corticosteroid metabolism, and that of the glucocorticoid receptor (NR3C1) in regulation of responsive genes, renders CYP3A4 and NR3C1 polymorphisms as potential candidates for pharmacogenetic analysis.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
1175-2203
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
4
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
331-41
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|
pubmed:dateRevised |
2008-11-21
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|
pubmed:meshHeading |
pubmed-meshheading:15462611-Adrenal Cortex Hormones,
pubmed-meshheading:15462611-Child,
pubmed-meshheading:15462611-Child, Preschool,
pubmed-meshheading:15462611-Cytochrome P-450 CYP3A,
pubmed-meshheading:15462611-Cytochrome P-450 Enzyme System,
pubmed-meshheading:15462611-Disease-Free Survival,
pubmed-meshheading:15462611-Female,
pubmed-meshheading:15462611-Genetic Predisposition to Disease,
pubmed-meshheading:15462611-Humans,
pubmed-meshheading:15462611-Infant,
pubmed-meshheading:15462611-Linkage Disequilibrium,
pubmed-meshheading:15462611-Male,
pubmed-meshheading:15462611-Multivariate Analysis,
pubmed-meshheading:15462611-Polymorphism, Genetic,
pubmed-meshheading:15462611-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:15462611-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:15462611-Probability,
pubmed-meshheading:15462611-Receptors, Glucocorticoid,
pubmed-meshheading:15462611-Survival Rate
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|
pubmed:year |
2004
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|
pubmed:articleTitle |
Polymorphisms in genes involved in the corticosteroid response and the outcome of childhood acute lymphoblastic leukemia.
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|
pubmed:affiliation |
Research Center, Sainte-Justine Hospital, Centre Hospitalier Universitaire Mère-Enfant, Montreal, Quebec, Canada.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|
