Linked Life Data

15461861

Source:http://linkedlifedata.com/resource/pubmed/id/15461861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-10-5
pubmed:abstractText
Cyclooxygenase (COX), the key enzyme in prostaglandin cascade, is expressed in two isoforms: the constitutive COX-1 and the inducible COX-2. Hyper-expression of COX-2 has been implicated in the pathogenesis of colon-rectal cancer in humans but it appears to play a significant role as a tumour progression factor also in other forms of human cancer, including oral cancer. The aim of this study was to analyze the expression of COX-2, at the protein level, in 45 cases of oral squamous cell carcinoma. Standard immunohistochemical streptavidin-biotin peroxidase analysis was carried out with highly specific antibody against human COX-2 and cell specific markers, in 45 oral squamous cell carcinomas. Our study revealed a moderate to high COX-2 expression in 35 out of the 45 oral squamous cell carcinoma specimens (77.8%). COX-2 expression appeared particularly abundant in the superficial ulcerated layers of relatively well differentiated carcinomas. However, we were unable to assess any statistically significant association between COX-2 hyper-expression and tumor site, tumor grading, tumor size, presence of lymph node metastases, tumor stage and age at onset, respectively. Interestingly, COX-2 expression was detected not only in areas of epithelial dysplasia adjacent to the primary layers (86% of the cases) but also in normal-appearing epithelium at the boundaries of squamous cell carcinoma (77%), indicating a possible involvement in tumour progression by the apparently normal tissue surrounding the lesion. Moreover, intense COX-2 staining was observed in endothelial cells of intra-tumour vessels and extra-tumour vessels adjacent to the tumour nests, in a high proportion of cases (82%). COX-2 positivity was associated with CD34 and VEGF positivity, indicating that these vessels were probably neo-formed ones. From this study as well as from other works, it appears that indeed COX-2 is over-expressed in this important human malignancy. However, further studies are necessary to understand the exact magnitude of this over-expression and, mostly, the possible role of COX-2 in the pathogenesis and progression of oral cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0394-6320
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-82
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:15461861-Aged, pubmed-meshheading:15461861-Blood Vessels, pubmed-meshheading:15461861-Carcinoma, Squamous Cell, pubmed-meshheading:15461861-Cyclooxygenase 2, pubmed-meshheading:15461861-Female, pubmed-meshheading:15461861-Gene Expression Regulation, Enzymologic, pubmed-meshheading:15461861-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15461861-Humans, pubmed-meshheading:15461861-Immunohistochemistry, pubmed-meshheading:15461861-Inflammation, pubmed-meshheading:15461861-Isoenzymes, pubmed-meshheading:15461861-Male, pubmed-meshheading:15461861-Membrane Proteins, pubmed-meshheading:15461861-Middle Aged, pubmed-meshheading:15461861-Mouth Neoplasms, pubmed-meshheading:15461861-Neovascularization, Pathologic, pubmed-meshheading:15461861-Prostaglandin-Endoperoxide Synthases
pubmed:articleTitle
Cyclooxygenase-2 expression in oral squamous cell carcinoma.
pubmed:affiliation
Department Biomorphological and Functional Sciences, University of Naples, Federico II, Naples, Italy.
pubmed:publicationType
Journal Article