Linked Life Data

15460441

Source:http://linkedlifedata.com/resource/pubmed/id/15460441

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2004-10-4
pubmed:abstractText
An optical purity test was indirectly performed on (S)-ibuprofen as its diastereomeric (R)-(+)-1-phenylethylamide derivative using achiral gas chromatography (GC). The method for the determination of trace (R)-ibuprofen (optical impurity), within the range 1.0 to 50 ng, from a racemic ibuprofen standard was linear (r = 0.9997) with acceptable precision (% RSD < or = 5.3) and accuracy (% RE = 0.7 - -3.9). Similar results were obtained with the method validation for the quantification of (S)-ibuprofen within the range 0.1 to 2.0 microg using a (S)-ibuprofen standard. When applied to seven different commercial (S)-ibuprofen products, their optical purities (98.7 - 99.1%) were determined with good precision (% RSD < or = 4.0).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0253-6269
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
820-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Optical purity determination of (S)-ibuprofen in tablets by achiral gas chromatography.
pubmed:affiliation
College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't