Source:http://linkedlifedata.com/resource/pubmed/id/15459967
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2004-11-19
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| pubmed:abstractText |
Fusogenic membrane glycoproteins (FMG) such as the gibbon ape leukemia virus envelope (GALV) glycoprotein are potent therapeutic transgenes with potential utility in the gene therapy of gliomas. Transfection of glioma cell lines with FMG expression constructs results in fusion with massive syncytia formation followed by cytotoxic cell death. Nevertheless, ubiquitous expression of the GALV receptor, Pit-1, makes targeting desirable in order to increase the specificity of the observed cytopathic effect. Here we report on use of matrix metalloproteinase (MMP)-cleavable linkers to target the cytotoxicity of FMG-expressing adenoviral vectors against gliomas.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1099-498X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
6
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1216-27
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15459967-Adenoviridae,
pubmed-meshheading:15459967-Animals,
pubmed-meshheading:15459967-Cell Count,
pubmed-meshheading:15459967-Cell Death,
pubmed-meshheading:15459967-Cell Fusion,
pubmed-meshheading:15459967-Cell Line, Tumor,
pubmed-meshheading:15459967-Cell Size,
pubmed-meshheading:15459967-Gene Therapy,
pubmed-meshheading:15459967-Genetic Vectors,
pubmed-meshheading:15459967-Giant Cells,
pubmed-meshheading:15459967-Glioma,
pubmed-meshheading:15459967-Humans,
pubmed-meshheading:15459967-Leukemia Virus, Gibbon Ape,
pubmed-meshheading:15459967-Matrix Metalloproteinases,
pubmed-meshheading:15459967-Membrane Glycoproteins,
pubmed-meshheading:15459967-Mice,
pubmed-meshheading:15459967-Transplantation, Heterologous,
pubmed-meshheading:15459967-Viral Proteins
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| pubmed:year |
2004
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| pubmed:articleTitle |
Adenoviral vectors expressing fusogenic membrane glycoproteins activated via matrix metalloproteinase cleavable linkers have significant antitumor potential in the gene therapy of gliomas.
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| pubmed:affiliation |
Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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