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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-10-1
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pubmed:abstractText |
15-Lipoxygenase (15-LO) is a nonheme iron-containing enzyme that catalyzes the peroxidation of fatty acids. Herein, we studied the effect of 15-LO overexpression in the vascular endothelium on thymocyte apoptosis by evaluating thymuses from low-density lipoprotein receptor-deficient (LDL-RD) mice and LDL-RD/15-LO mice. Thymuses were evaluated by immunohistochemistry and by TUNEL whereas in vitro studies were carried out by employing freshly isolated thymocytes from the respective mice and evaluation of apoptosis by propidium iodide and annexin V cytometry. METHODS and
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonate 15-Lipoxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Proteinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/benzyloxycarbonyl...
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pubmed:status |
MEDLINE
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pubmed:issn |
1015-2008
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
261-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15459485-Acetylcysteine,
pubmed-meshheading:15459485-Animals,
pubmed-meshheading:15459485-Antioxidants,
pubmed-meshheading:15459485-Apoptosis,
pubmed-meshheading:15459485-Arachidonate 15-Lipoxygenase,
pubmed-meshheading:15459485-Caspase 3,
pubmed-meshheading:15459485-Caspases,
pubmed-meshheading:15459485-Cells, Cultured,
pubmed-meshheading:15459485-Clonal Deletion,
pubmed-meshheading:15459485-Cysteine Proteinase Inhibitors,
pubmed-meshheading:15459485-Endothelium, Vascular,
pubmed-meshheading:15459485-Humans,
pubmed-meshheading:15459485-Mice,
pubmed-meshheading:15459485-Mice, Inbred C57BL,
pubmed-meshheading:15459485-Mice, Knockout,
pubmed-meshheading:15459485-Mice, Transgenic,
pubmed-meshheading:15459485-Oligopeptides,
pubmed-meshheading:15459485-Receptors, LDL,
pubmed-meshheading:15459485-T-Lymphocytes,
pubmed-meshheading:15459485-Thymus Gland
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pubmed:year |
2004
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pubmed:articleTitle |
Overexpression of 15-lipoxygenase in the vascular endothelium is associated with increased thymic apoptosis in LDL receptor-deficient mice.
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pubmed:affiliation |
Institute of Pathology, Sheba Medical Center, Tel Hashomer, Israel.
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pubmed:publicationType |
Journal Article
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