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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-9-30
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pubmed:abstractText |
This study evaluated the efficacy and toxicity of ifosfamide and doxorubicin chemotherapy regimen in Turkish patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) previously treated with platinum-based chemotherapy. Twenty-one patients with recurrent or metastatic NPC previously treated with platinum-based chemotherapy as adjuvant or palliative treatments who received ifosfamide 2500 mg/m(2) d 1-3, mesna 2500 mg/m(2) d 1-3, doxorubicin 60 mg/m(2) d 1, repeated every 21 d was retrospectively analyzed. Patients received a median number of three cycles of ifosfamide-doxorubicin (range: 1-6). Seven patients (33.3%) achieved partial response and no patient achieved complete response. Six (28.5%) had stable disease, whereas three (18.75%) had progressive disease. The median time to progression was 7.0 mo. Ifosfamide-doxorubicin regimen is an effective salvage regimen in patients with recurrent and metastatic NPC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorouracil,
http://linkedlifedata.com/resource/pubmed/chemical/Ifosfamide
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pubmed:status |
MEDLINE
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pubmed:issn |
1357-0560
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15456947-Adolescent,
pubmed-meshheading:15456947-Adult,
pubmed-meshheading:15456947-Antibiotics, Antineoplastic,
pubmed-meshheading:15456947-Antimetabolites, Antineoplastic,
pubmed-meshheading:15456947-Antineoplastic Agents,
pubmed-meshheading:15456947-Antineoplastic Agents, Alkylating,
pubmed-meshheading:15456947-Cisplatin,
pubmed-meshheading:15456947-Combined Modality Therapy,
pubmed-meshheading:15456947-Data Interpretation, Statistical,
pubmed-meshheading:15456947-Disease Progression,
pubmed-meshheading:15456947-Doxorubicin,
pubmed-meshheading:15456947-Female,
pubmed-meshheading:15456947-Fluorouracil,
pubmed-meshheading:15456947-Humans,
pubmed-meshheading:15456947-Ifosfamide,
pubmed-meshheading:15456947-Male,
pubmed-meshheading:15456947-Middle Aged,
pubmed-meshheading:15456947-Nasopharyngeal Neoplasms,
pubmed-meshheading:15456947-Neoplasm Metastasis,
pubmed-meshheading:15456947-Neoplasm Recurrence, Local,
pubmed-meshheading:15456947-Retrospective Studies,
pubmed-meshheading:15456947-Salvage Therapy,
pubmed-meshheading:15456947-Software,
pubmed-meshheading:15456947-Time Factors,
pubmed-meshheading:15456947-Treatment Outcome
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pubmed:year |
2004
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pubmed:articleTitle |
Salvage ifosfamide-doxorubicin chemotherapy in patients with recurrent nasopharyngeal carcinoma pretreated with Cisplatin-based chemotherapy.
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pubmed:affiliation |
Department of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey. drkadri@usa.net
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pubmed:publicationType |
Journal Article,
Comparative Study
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