| pubmed-article:15456795 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15456795 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:15456795 | lifeskim:mentions | umls-concept:C1185739 | lld:lifeskim |
| pubmed-article:15456795 | lifeskim:mentions | umls-concept:C0521329 | lld:lifeskim |
| pubmed-article:15456795 | lifeskim:mentions | umls-concept:C0164209 | lld:lifeskim |
| pubmed-article:15456795 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:15456795 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15456795 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:15456795 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:15456795 | lifeskim:mentions | umls-concept:C0205386 | lld:lifeskim |
| pubmed-article:15456795 | lifeskim:mentions | umls-concept:C1709701 | lld:lifeskim |
| pubmed-article:15456795 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15456795 | pubmed:dateCreated | 2005-1-17 | lld:pubmed |
| pubmed-article:15456795 | pubmed:abstractText | Selective ablation of spinal neurons possessing substance P receptors (NK-1 receptors) using the selective cytotoxin conjugate substance P-saporin (SP-SAP) decreases hyperalgesia and central sensitization. The mechanisms by which NK-1 expressing neurons modulate the excitability of other dorsal horn neurons are unclear. Because the majority of NK-1 expressing spinal neurons project rostrally, it is possible that they are part of a spinal-supraspinal circuitry that contributes to descending modulation of excitability of spinal nociceptive neurons. We therefore determined whether ablation of spinal neurons that possess the NK-1 receptor altered descending systems that travel via the dorsolateral funiculus (DLF). Spontaneous activity and responses of dorsal horn neurons evoked by mechanical (von Frey monofilaments) and heat (35-51 degrees C) stimuli were determined before and after transection of the DLF and were compared in rats pretreated with intrathecal application of vehicle or SP-SAP. In vehicle-treated rats, transection of the DLF caused a 233% increase in mean spontaneous activity of neurons and enhanced their responses to mechanical and heat stimuli, whereas these increases in excitation were blocked in rats pretreated with SP-SAP. Importantly, SP-SAP alone had no effect on spontaneous or evoked activity in the absence of DLF transection. These results demonstrate that spinal neurons expressing the NK-1 receptor appear to play a pivotal role in regulating descending systems that modulate activity of nociceptive dorsal horn neurons. | lld:pubmed |
| pubmed-article:15456795 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15456795 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15456795 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15456795 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15456795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15456795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15456795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15456795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15456795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15456795 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15456795 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15456795 | pubmed:issn | 0022-3077 | lld:pubmed |
| pubmed-article:15456795 | pubmed:author | pubmed-author:MantyhPatrick... | lld:pubmed |
| pubmed-article:15456795 | pubmed:author | pubmed-author:GhilardiJosep... | lld:pubmed |
| pubmed-article:15456795 | pubmed:author | pubmed-author:KhasabovSerge... | lld:pubmed |
| pubmed-article:15456795 | pubmed:author | pubmed-author:SimoneDonald... | lld:pubmed |
| pubmed-article:15456795 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15456795 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:15456795 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15456795 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15456795 | pubmed:pagination | 998-1006 | lld:pubmed |
| pubmed-article:15456795 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:meshHeading | pubmed-meshheading:15456795... | lld:pubmed |
| pubmed-article:15456795 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15456795 | pubmed:articleTitle | Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus. | lld:pubmed |
| pubmed-article:15456795 | pubmed:affiliation | Department of Oral Sciences, University of Minnesota, Minneapolis, MN 55455, USA. | lld:pubmed |
| pubmed-article:15456795 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15456795 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15456795 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15456795 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15456795 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15456795 | lld:pubmed |
