Source:http://linkedlifedata.com/resource/pubmed/id/15455263
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2005-1-19
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| pubmed:abstractText |
Several recent case-control studies have examined the association between single nucleotide polymorphisms (SNPs) in the promoter region of the apolipoprotein E gene (APOE) and risk of Alzheimer disease (AD), with conflicting results. We assessed the relation between five APOE region SNPs and risk of AD in both case-control and family-based analyses. We observed a statistically significant association with the +5361T allele in the overall case-control analysis (P value=0.04) after adjusting for the known effect of the APOE-4 allele. Further analysis revealed this association to be limited to carriers of the APOE-4 allele. Age-stratified analyses in the patients with age at onset of 80 years or greater and age-matched controls showed that the -219T allele (P value=0.009) and the +113C allele (P value=0.03) are associated with increased risk of AD. Despite these findings, haplotype and family-based association analyses were unable to provide evidence that the APOE region SNPs influenced risk of AD independent of the APOE-4 allele. In addition to risk, we tested for association between the SNPs and age at onset of AD, but found no association in the case-control or family based analyses. In conclusion, SNPs +5361, or a SNP in strong linkage disequilibrium, may confer some additional risk for developing AD beyond the risk due to APOE-4; however, the effect independent of APOE-4 is likely to be small.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1364-6745
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| pubmed:author |
pubmed-author:GilbertJohn RJR,
pubmed-author:HainesJonathan LJL,
pubmed-author:MartinEden RER,
pubmed-author:NicodemusKristin KKK,
pubmed-author:Pericak-VanceMargaret AMA,
pubmed-author:RosesAllen DAD,
pubmed-author:SaundersAnn MAM,
pubmed-author:SchmechelDonald EDE,
pubmed-author:StengerJudith EJE,
pubmed-author:VanceJeffery MJM,
pubmed-author:Welsh-BohmerKathleen AKA
|
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
201-8
|
| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15455263-Age of Onset,
pubmed-meshheading:15455263-Aged,
pubmed-meshheading:15455263-Aged, 80 and over,
pubmed-meshheading:15455263-Alzheimer Disease,
pubmed-meshheading:15455263-Apolipoprotein E4,
pubmed-meshheading:15455263-Apolipoproteins E,
pubmed-meshheading:15455263-Case-Control Studies,
pubmed-meshheading:15455263-Family Health,
pubmed-meshheading:15455263-Female,
pubmed-meshheading:15455263-Genetic Predisposition to Disease,
pubmed-meshheading:15455263-Haplotypes,
pubmed-meshheading:15455263-Humans,
pubmed-meshheading:15455263-Linkage Disequilibrium,
pubmed-meshheading:15455263-Male,
pubmed-meshheading:15455263-Polymorphism, Genetic,
pubmed-meshheading:15455263-Risk Factors
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease.
|
| pubmed:affiliation |
Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|