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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021469,
umls-concept:C0034678,
umls-concept:C0035820,
umls-concept:C0185117,
umls-concept:C0205314,
umls-concept:C0206745,
umls-concept:C0233820,
umls-concept:C0242339,
umls-concept:C0623362,
umls-concept:C0679622,
umls-concept:C0717550,
umls-concept:C0919336,
umls-concept:C0965129,
umls-concept:C1280500,
umls-concept:C1539081,
umls-concept:C1563937,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
2004-9-29
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pubmed:abstractText |
There is increasing evidence of cross-talk between renin-angiotensin system (RAS) and dyslipidemia in atherogenesis mediated via activation of inflammatory cascade, involving CD40 and matrix metalloproteinases (MMPs). We postulated that inhibition of RAS with candesartan and dyslipidemia with rosuvastatin would have additive inhibitory effect on CD40 and MMPs expression and atherogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...,
http://linkedlifedata.com/resource/pubmed/chemical/candesartan,
http://linkedlifedata.com/resource/pubmed/chemical/rosuvastatin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0160-2446
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
446-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15454852-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:15454852-Animals,
pubmed-meshheading:15454852-Antigens, CD40,
pubmed-meshheading:15454852-Apolipoproteins E,
pubmed-meshheading:15454852-Arteriosclerosis,
pubmed-meshheading:15454852-Benzimidazoles,
pubmed-meshheading:15454852-Cholesterol,
pubmed-meshheading:15454852-Drug Synergism,
pubmed-meshheading:15454852-Drug Therapy, Combination,
pubmed-meshheading:15454852-Female,
pubmed-meshheading:15454852-Fluorobenzenes,
pubmed-meshheading:15454852-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:15454852-Hyperlipidemias,
pubmed-meshheading:15454852-Male,
pubmed-meshheading:15454852-Matrix Metalloproteinases,
pubmed-meshheading:15454852-Mice,
pubmed-meshheading:15454852-Mice, Inbred C57BL,
pubmed-meshheading:15454852-Mice, Knockout,
pubmed-meshheading:15454852-Pyrimidines,
pubmed-meshheading:15454852-RNA, Messenger,
pubmed-meshheading:15454852-Renin-Angiotensin System,
pubmed-meshheading:15454852-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15454852-Sulfonamides,
pubmed-meshheading:15454852-Tetrazoles,
pubmed-meshheading:15454852-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:15454852-Tissue Inhibitor of Metalloproteinase-2
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pubmed:year |
2004
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pubmed:articleTitle |
Inhibitory effect of candesartan and rosuvastatin on CD40 and MMPs expression in apo-E knockout mice: novel insights into the role of RAS and dyslipidemia in atherogenesis.
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pubmed:affiliation |
Department of Internal Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205-7199, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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