Linked Life Data

15452304

Source:http://linkedlifedata.com/resource/pubmed/id/15452304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-9-28
pubmed:abstractText
The authors analyzed the female: male (F:M) ratio according to the HLA-DRB1-DQB1 genotype in a cohort of multiple sclerosis (MS) patients from Sardinia, where the disease is associated with DR3 and DR4. In the whole cohort of 1,097 patients, F:M ratio was 2.24; however, it was 2.88 in DR3/DR3 and 2.52 in DR3/DRX (X#DR3 and DR4) individuals. Parental transmission of DR3 and DR4, assessed in a set of 565 case-parent triads, showed evidence of paternal inheritance of DR3 in affected women, thus explaining the excess of females in the DR3 category.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1526-632X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1084-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15452304-Alleles, pubmed-meshheading:15452304-Chromosome Segregation, pubmed-meshheading:15452304-Cohort Studies, pubmed-meshheading:15452304-Fathers, pubmed-meshheading:15452304-Female, pubmed-meshheading:15452304-Gene Frequency, pubmed-meshheading:15452304-Genes, MHC Class II, pubmed-meshheading:15452304-Genetic Predisposition to Disease, pubmed-meshheading:15452304-HLA-DQ Antigens, pubmed-meshheading:15452304-HLA-DQ beta-Chains, pubmed-meshheading:15452304-HLA-DR Antigens, pubmed-meshheading:15452304-HLA-DR3 Antigen, pubmed-meshheading:15452304-HLA-DR4 Antigen, pubmed-meshheading:15452304-HLA-DRB1 Chains, pubmed-meshheading:15452304-Haplotypes, pubmed-meshheading:15452304-Humans, pubmed-meshheading:15452304-Italy, pubmed-meshheading:15452304-Logistic Models, pubmed-meshheading:15452304-Male, pubmed-meshheading:15452304-Multiple Sclerosis, pubmed-meshheading:15452304-Sex Distribution, pubmed-meshheading:15452304-Siblings
pubmed:year
2004
pubmed:articleTitle
Bias in parental transmission of the HLA-DR3 allele in Sardinian multiple sclerosis.
pubmed:affiliation
Multiple Sclerosis Center, University of Cagliari, Italy. gmarrosu@unica.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't