15452069

Source:http://linkedlifedata.com/resource/pubmed/id/15452069

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0024400, umls-concept:C0031978, umls-concept:C0034121, umls-concept:C0456389, umls-concept:C1280500, umls-concept:C1832072
pubmed:issue	10
pubmed:dateCreated	2004-9-28
pubmed:abstractText	Pirenzepine is suggested to be a relatively selective muscarinic (M(1)) antagonist and is currently under investigation for the treatment of myopia. Atropine, a nonselective M-type antagonist, is used in the treatment of myopia, but has undesired ocular and systemic side effects. An M(1)-specific antagonist may decrease side effects and remain effective at reducing the progression of myopia. In the current study, the effects of pirenzepine on pupil diameter, resting refraction, and accommodation were studied in rhesus monkeys.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/1 R01 EY014651, http://linkedlifedata.com/resource/pubmed/grant/5 T32 EY07024, http://linkedlifedata.com/resource/pubmed/grant/P30 EY07751, http://linkedlifedata.com/resource/pubmed/grant/R01 EY014651-01
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7703701
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Carbachol, http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Ophthalmic Solutions, http://linkedlifedata.com/resource/pubmed/chemical/Pirenzepine
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0146-0404
pubmed:author	pubmed-author:FrishmanLaura JLJ, pubmed-author:GlasserAdrianA, pubmed-author:OstrinLisa ALA
pubmed:issnType	Print
pubmed:volume	45
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3620-8
pubmed:dateRevised	2010-9-30
pubmed:meshHeading	pubmed-meshheading:15452069-Accommodation, Ocular, pubmed-meshheading:15452069-Animals, pubmed-meshheading:15452069-Carbachol, pubmed-meshheading:15452069-Conjunctiva, pubmed-meshheading:15452069-Electrodes, Implanted, pubmed-meshheading:15452069-Injections, pubmed-meshheading:15452069-Macaca mulatta, pubmed-meshheading:15452069-Microelectrodes, pubmed-meshheading:15452069-Muscarinic Antagonists, pubmed-meshheading:15452069-Ophthalmic Solutions, pubmed-meshheading:15452069-Pirenzepine, pubmed-meshheading:15452069-Pupil, pubmed-meshheading:15452069-Refraction, Ocular
pubmed:year	2004
pubmed:articleTitle	Effects of pirenzepine on pupil size and accommodation in rhesus monkeys.
pubmed:affiliation	College of Optometry, University of Houston, Houston, Texas 77204, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't