15450170

Source:http://linkedlifedata.com/resource/pubmed/id/15450170

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001811, umls-concept:C0025260, umls-concept:C0439064, umls-concept:C0935584, umls-concept:C1521761, umls-concept:C1524003, umls-concept:C2347957
pubmed:issue	1
pubmed:dateCreated	2004-9-28
pubmed:abstractText	Memory decline in aging results from multiple factors that influence both executive function and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems are preferentially vulnerable to white matter change, atrophy, and certain forms of neurotransmitter depletion. Frontal-striatal change may underlie mild memory difficulties in aging that are most apparent on tasks demanding high levels of attention and controlled processing. Through separate mechanisms, Alzheimer's disease preferentially affects the medial temporal lobe and cortical networks, including posterior cingulate and retrosplenial cortex early in its progression, often before clinical symptoms are recognized. Disruption of the medial temporal lobe memory system leads directly to memory impairment. Recent findings further suggest that age-associated change is not received passively. Reliance on reserve is emerging as an important factor that determines who ages gracefully and who declines rapidly. Functional imaging studies, in particular, suggest increased recruitment of brain areas in older adults that may reflect a form of compensation.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/P01 AG03991, http://linkedlifedata.com/resource/pubmed/grant/P01 AG05681
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8809320
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0896-6273
pubmed:author	pubmed-author:BucknerRandy LRL
pubmed:issnType	Print
pubmed:day	30
pubmed:volume	44
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	195-208
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:15450170-Aging, pubmed-meshheading:15450170-Alzheimer Disease, pubmed-meshheading:15450170-Animals, pubmed-meshheading:15450170-Humans, pubmed-meshheading:15450170-Memory
pubmed:year	2004
pubmed:articleTitle	Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate.
pubmed:affiliation	Howard Hughes Medical Institute, Washington University in St. Louis, Department of Psychology, One Brookings Drive, Campus Box 1125, St. Louis, MO 63130, USA. rbuckner@artsci.wustl.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't