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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-9-28
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pubmed:abstractText |
Anti-viral host defense harbors a variety of strategies to coup with viral infection. Recent findings suggested that Toll-like receptors (TLRs) and their signaling pathways involve type I IFN induction in response to virus-specific molecular patterns. TLR 3 and TLR 4 in myeloid dendritic cells (mDCs) recognize viral dsRNA and putative viral products, respectively, to induce IFN-beta via IRF-3 activation. On the other hand, TLR 7 and TLR 9 in plasmacytoid DCs (pDCs) induce IFN-alpha in response to their ligands, U/G-rich ssRNA and non-methylated CpG DNA. We identified TICAM-1 which is recruited to the cytoplasmic domain (designated TIR) of TLR 3 and allows to select the pathway to activation of IRF-3. We also identified TICAM-2 which binds TLR 4 and together with TICAM-1 activates IRF-3. TICAM-1 knockdown by RNAi supported the key role of TICAM-1 in IFN-beta induction. Hence, the IFN-beta induction in mDCs appears in part due to the function of TICAM-1. Viruses are known to activate kinases that directly activate IRF-3 inside the cells, and this pathway may merge with the TLR 3-TICAM-1 pathway. Here we review the relationship between the TLR 3-TICAM-1 pathway and viral infection.
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pubmed:language |
jpn
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Vesicular...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IRF3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-3,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/TICAM1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TLR3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TLR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TLR7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TLR9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 3,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 7,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 9,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0042-6857
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-8
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pubmed:dateRevised |
2011-2-9
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pubmed:meshHeading |
pubmed-meshheading:15449898-Adaptor Proteins, Vesicular Transport,
pubmed-meshheading:15449898-Animals,
pubmed-meshheading:15449898-Bone Marrow Cells,
pubmed-meshheading:15449898-DNA-Binding Proteins,
pubmed-meshheading:15449898-Dendritic Cells,
pubmed-meshheading:15449898-Humans,
pubmed-meshheading:15449898-Interferon Regulatory Factor-3,
pubmed-meshheading:15449898-Interferon Type I,
pubmed-meshheading:15449898-Interferon-alpha,
pubmed-meshheading:15449898-Interferon-beta,
pubmed-meshheading:15449898-Membrane Glycoproteins,
pubmed-meshheading:15449898-Receptors, Cell Surface,
pubmed-meshheading:15449898-Signal Transduction,
pubmed-meshheading:15449898-Toll-Like Receptor 3,
pubmed-meshheading:15449898-Toll-Like Receptor 4,
pubmed-meshheading:15449898-Toll-Like Receptor 7,
pubmed-meshheading:15449898-Toll-Like Receptor 9,
pubmed-meshheading:15449898-Toll-Like Receptors,
pubmed-meshheading:15449898-Transcription Factors,
pubmed-meshheading:15449898-Virus Diseases,
pubmed-meshheading:15449898-Viruses
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pubmed:year |
2004
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pubmed:articleTitle |
[Toll-like receptors that sense viral infection].
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pubmed:affiliation |
Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka, 537-8511, Japan. seya-tu@med.hokudai.ac.jp
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pubmed:publicationType |
Journal Article,
English Abstract,
Review
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