Linked Life Data

15449809

Source:http://linkedlifedata.com/resource/pubmed/id/15449809

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-9-28
pubmed:abstractText
We have tested the effect of topical administration of 0.5% para-amino-clonidine (PAC), an adrenergic alpha 2 agonist, on intraocular pressure (IOP), protein and prostaglandin E2 (PGE2) concentration in aqueous humor following the laser application to the iris of albino rabbits. The irides received Q-switched Nd: YAG laser irradiation with the energy level ranging from 2 to 80 mJ with and without topical administration of PAC one-hour prior to and immediately following laser irradiation. The IOP was measured with an Alcon pneumotonometer prior to and hourly for 6-hours following laser application. Aqueous humor was withdrawn prior to and at 0.5, 1, 2, 4 hours following laser irradiation for determining protein (Lowry method) and PGE2 (radioimmunoassay). Four to 6 rabbits were used for each experiment. The increase in IOP, protein and PGE2 concentration following laser irradiation was demonstrated to be dependent on the amount of laser energy. PAC significantly suppressed the IOP rise and the elevation of protein content, while it failed to affect the increase in PGE2.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0385-0005
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
The effect of alpha2-agonist on IOP rise following Nd-YAG laser iridotomy.
pubmed:affiliation
Department of Ophthalmology, Tokai University School of Medicine, Bohseidai, Isehara-shi, Kanagawa 259-1193, Japan. k-kawai@is.icc.u-tokai.ac.jp
pubmed:publicationType
Journal Article