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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-9-27
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pubmed:abstractText |
In all, 236 adults with newly diagnosed acute lymphoblastic leukemia (ALL) were randomly assigned to receive either granulocyte colony-stimulating factor (G-CSF), or granulocyte-macrophage CSF (GM-CSF), or no CSF during a 4-week 4-drugs induction chemotherapy. Two successive trials were performed. CSFs were given from the last infusion of anthracycline in Trial 1 or from day 4 of induction therapy in Trial 2 until neutrophil recovery. A total of 95 patients were included in the G-CSF group, 67 in the GM-CSF group, and 74 in the control group. Overall, CSFs showed a trend for a reduced incidence of severe infections and of days with antibiotics. Median time for neutrophil recovery was 17 days with G-CSF, 18 days with GM-CSF, and 21 days without CSF. In Trial 2, duration of hospitalization was significantly lower in the G-CSF group than in the other groups (P < 0.05). Time to neutrophil recovery was also significantly shorter (P < 0.05) and severe infections were lower in the G-CSF group (P = 0.01). CR rate was higher in the GM-CSF group as compared to the control group. This tended to be confirmed for the most aggressive ALL and was statistically significant for Philadelphia-positive ALL after salvage therapy (P = 0.04). There were no significant differences between the three groups in terms of disease-free survival.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1466-4860
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pubmed:author |
pubmed-author:BoironJean-MichelJM,
pubmed-author:BoulatOlivierO,
pubmed-author:EspinouseDanielD,
pubmed-author:FiereDenisD,
pubmed-author:GarbanFrédéricF,
pubmed-author:GardinClaudeC,
pubmed-author:Groupe d'Etude et de Traitement de la Leucémie Aiguë Lymphoblastique de...,
pubmed-author:HuguetFrançoiseF,
pubmed-author:LhéritierVéroniqueV,
pubmed-author:RemanOumedalyO,
pubmed-author:SuttonLaurentL,
pubmed-author:ThomasXavierX,
pubmed-author:TurlurePascalP
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
384-94
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15448664-Adolescent,
pubmed-meshheading:15448664-Adult,
pubmed-meshheading:15448664-Anti-Bacterial Agents,
pubmed-meshheading:15448664-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15448664-Combined Modality Therapy,
pubmed-meshheading:15448664-Cyclophosphamide,
pubmed-meshheading:15448664-Daunorubicin,
pubmed-meshheading:15448664-Disease-Free Survival,
pubmed-meshheading:15448664-Drug Utilization,
pubmed-meshheading:15448664-Female,
pubmed-meshheading:15448664-Fever,
pubmed-meshheading:15448664-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:15448664-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:15448664-Hospitalization,
pubmed-meshheading:15448664-Humans,
pubmed-meshheading:15448664-Idarubicin,
pubmed-meshheading:15448664-Infection,
pubmed-meshheading:15448664-Infection Control,
pubmed-meshheading:15448664-Leukocyte Count,
pubmed-meshheading:15448664-Male,
pubmed-meshheading:15448664-Middle Aged,
pubmed-meshheading:15448664-Neutropenia,
pubmed-meshheading:15448664-Neutrophils,
pubmed-meshheading:15448664-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:15448664-Prednisone,
pubmed-meshheading:15448664-Prospective Studies,
pubmed-meshheading:15448664-Remission Induction,
pubmed-meshheading:15448664-Salvage Therapy,
pubmed-meshheading:15448664-Time Factors,
pubmed-meshheading:15448664-Treatment Outcome,
pubmed-meshheading:15448664-Vincristine
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pubmed:year |
2004
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pubmed:articleTitle |
Efficacy of granulocyte and granulocyte-macrophage colony-stimulating factors in the induction treatment of adult acute lymphoblastic leukemia: a multicenter randomized study.
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pubmed:affiliation |
Service d'Hématologie, Hôpital Edouard Herriot, 69437, Lyon Cedex 03, France. xavier.thomas@chu-lyon.fr
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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