Linked Life Data

15447735

Source:http://linkedlifedata.com/resource/pubmed/id/15447735

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-9-27
pubmed:abstractText
Lidocaine is metabolized by cytochrome P450 3A4 and 1A2 enzymes (CYP3A4 and CYP1A2) in vitro. However, their relative contribution to the elimination of lidocaine depends on lidocaine concentration. We have studied the effect of a potent CYP3A4 inhibitor, itraconazole, on the pharmacokinetics of inhaled lidocaine in ten healthy volunteers using a randomized, two-phase cross-over study design. The interval between the phases was four weeks. The subjects were given orally itraconazole (200 mg once a day) or placebo for four days. On day 4, each subject inhaled a single dose of 1.5 mg/kg of lidocaine by nebulizer. Plasma samples were collected until 10 hr and the concentrations of lidocaine and its major metabolite monoethylglycinexylidide were measured by gas chromatography. The areas under the lidocaine and monoethylglycinexylidide concentration time curves were similar during both phases. No statistically significant differences were observed in any of the pharmacokinetic parameters; peak concentrations, concentration peak times or elimination half-lives of lidocaine or monoethylglycinexylidide. The clinical implication of this study is that no lidocaine dosage adjustments are necessary if it is used to prepare the airway prior to endoscopic procedures or intubation in patients using itraconazole or other inhibitors of CYP3A4.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1742-7835
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
120-3
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Effect of itraconazole on the pharmacokinetics of inhaled lidocaine.
pubmed:affiliation
Department of Anaesthesia, Diacor Hospital, Helsinki, Finland. mika.isohanni@diacor.fi
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't