Linked Life Data

1544610

Source:http://linkedlifedata.com/resource/pubmed/id/1544610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-4-15
pubmed:abstractText
Grilled ground beef contains a number of carcinogens, including aminoimidazoazaarenes, such as 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), as well as anticarcinogenic substances, such as heat-generated derivatives of linoleic acid (CLA). In the present study, CLA was administered by gavage every other day to young adult CDF1 mice for a period of 45 days (50 microliters/48 hr for days 1-24 and 100 microliters/48 hr for days 25-45), using trioctanoin as a control. On day 46 all animals received a single oral dose (50 mg/kg) of IQ and tissues were collected 24 hr later. Tissue DNA was purified and analysed for IQ-DNA adducts by 32P-postlabelling assays. Compared with controls, CLA treatment caused a 43.1 and 31.8% inhibition of adduct formation in the livers of male and female mice, respectively. In the lung and large intestine CLA had a 74.2 and 39.4% inhibitory effect, respectively, in the female only, whereas there was no effect in the stomach or small intestine of either sex. In the kidneys of females, CLA treatment inhibited IQ-DNA adduct formation almost completely (95.2%), whereas in the kidneys of males CLA had no effect. It is concluded that CLA inhibits IQ-DNA adduct formation in certain IQ target organs (liver and lung) and non-target organs (large intestine, kidney), but is inactive in other target organs (stomach) and non-target organs (small intestine) of the CDF1 mouse.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0278-6915
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-16
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adduct formation in CDF1 mice by heat-altered derivatives of linoleic acid.
pubmed:affiliation
Department of Pathology, Medical College of Ohio, Toledo 43699.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't