pubmed-article:1544223 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:1544223 | lifeskim:mentions | umls-concept:C1411980 | lld:lifeskim |
pubmed-article:1544223 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:1544223 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:1544223 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:1544223 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
pubmed-article:1544223 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:1544223 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:1544223 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:1544223 | pubmed:dateCreated | 1992-4-13 | lld:pubmed |
pubmed-article:1544223 | pubmed:abstractText | Mycobacterium avium is an opportunistic pathogen that infects individuals suffering from chronic lung disease or immunocompromised patients such as AIDS patients. Here we show that a highly virulent isolate of M. avium proliferated as extensively in T cell deficient as in immunocompetent mice. T cell deficient mice allowed a progressive growth of a less virulent AIDS-derived isolate of M. avium while immunocompetent mice arrested the growth of this isolate. Adoptive transfer of T cell enriched spleen cells between congenic strains of mice differing at the Bcg/Ity/Lsh locus showed that only naturally resistant BALB/c.Bcgr (C.D2) mice infected with the highly virulent strain of M. avium or the naturally susceptible BALB/c mice infected with the lower virulence isolate developed protective T cells and that these cells only mediated protection when transferred to naturally susceptible, but not to naturally resistant, mice. Both strains of M. avium proliferated in bone marrow-derived macrophages cultured in vitro and they were both susceptible to the bacteriostatic effects induced in the macrophages by crude lymphokines produced by concanavalin A-stimulated spleen cells. | lld:pubmed |
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pubmed-article:1544223 | pubmed:language | eng | lld:pubmed |
pubmed-article:1544223 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1544223 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:1544223 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1544223 | pubmed:month | Mar | lld:pubmed |
pubmed-article:1544223 | pubmed:issn | 0009-9104 | lld:pubmed |
pubmed-article:1544223 | pubmed:author | pubmed-author:AppelbergRR | lld:pubmed |
pubmed-article:1544223 | pubmed:author | pubmed-author:PedrosaJJ | lld:pubmed |
pubmed-article:1544223 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1544223 | pubmed:volume | 87 | lld:pubmed |
pubmed-article:1544223 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1544223 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:1544223 | pubmed:pagination | 379-85 | lld:pubmed |
pubmed-article:1544223 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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pubmed-article:1544223 | pubmed:year | 1992 | lld:pubmed |
pubmed-article:1544223 | pubmed:articleTitle | Induction and expression of protective T cells during Mycobacterium avium infections in mice. | lld:pubmed |
pubmed-article:1544223 | pubmed:affiliation | Centro de Citologia Experimental (Instituto Nacional de Investigação Cientifica), University of Porto, Portugal. | lld:pubmed |
pubmed-article:1544223 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:1544223 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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