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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-4-13
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pubmed:abstractText |
Mycobacterium avium is an opportunistic pathogen that infects individuals suffering from chronic lung disease or immunocompromised patients such as AIDS patients. Here we show that a highly virulent isolate of M. avium proliferated as extensively in T cell deficient as in immunocompetent mice. T cell deficient mice allowed a progressive growth of a less virulent AIDS-derived isolate of M. avium while immunocompetent mice arrested the growth of this isolate. Adoptive transfer of T cell enriched spleen cells between congenic strains of mice differing at the Bcg/Ity/Lsh locus showed that only naturally resistant BALB/c.Bcgr (C.D2) mice infected with the highly virulent strain of M. avium or the naturally susceptible BALB/c mice infected with the lower virulence isolate developed protective T cells and that these cells only mediated protection when transferred to naturally susceptible, but not to naturally resistant, mice. Both strains of M. avium proliferated in bone marrow-derived macrophages cultured in vitro and they were both susceptible to the bacteriostatic effects induced in the macrophages by crude lymphokines produced by concanavalin A-stimulated spleen cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-1090526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-16557782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-1986381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-2115416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-2116245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-2294152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-2471938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-2492259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-2524273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-2673999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-2762766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-2933483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3023238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3097148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3129497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3137164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3141288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3146817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3146818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3262585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3283260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3332058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3535595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3541122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-369415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3759239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3804446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3891623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3904604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-3919979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-4173819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-5002230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-6311901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-6358358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-6361135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544223-6698599
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
379-85
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1544223-Animals,
pubmed-meshheading:1544223-Colony Count, Microbial,
pubmed-meshheading:1544223-Immunity,
pubmed-meshheading:1544223-Immunocompetence,
pubmed-meshheading:1544223-Immunotherapy, Adoptive,
pubmed-meshheading:1544223-Lymphocyte Activation,
pubmed-meshheading:1544223-Macrophages,
pubmed-meshheading:1544223-Mice,
pubmed-meshheading:1544223-Mice, Inbred Strains,
pubmed-meshheading:1544223-Mycobacterium avium,
pubmed-meshheading:1544223-T-Lymphocytes,
pubmed-meshheading:1544223-Tuberculosis,
pubmed-meshheading:1544223-Virulence
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pubmed:year |
1992
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pubmed:articleTitle |
Induction and expression of protective T cells during Mycobacterium avium infections in mice.
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pubmed:affiliation |
Centro de Citologia Experimental (Instituto Nacional de Investigação Cientifica), University of Porto, Portugal.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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