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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-4-13
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pubmed:abstractText |
Anti-neural antibodies have been implicated to play a role in the pathogenesis of nerve damage in leprosy patients. To find the relationship between anti-neural antibodies and clinical findings, we attempted to detect antibodies against neurofilament-enriched proteins by ELISA in sera from leprosy patients. Of 289 sera from leprosy patients, 74 (25.6%) had significant anti-neural antibodies; in contrast, 1 (5.0%) of 20 tuberculosis patients and 11 (7.1%) of 154 controls were seroreactive to nerve antigen. When clinical types were considered, a significant level of anti-neural IgG antibodies was detectable in 53 (30.1%) of 176 sera from lepromatous patients compared with 21 (18.6%) of 113 sera from tuberculoid patients, indicating that lepromatous patients were more likely to be seropositive to nerve antigens in ELISA. Some of the ELISA-reactive sera showed antibody reactivity with 38-kD, 40-kD and 43-kD nerve antigens in Western blotting analysis. There was no apparent correlation between seroreactivity to nerve antigens and bacterial load in leprosy patients. Although there was no statistical significance, anti-neural antibodies were detectable more often among the patients on chemotherapy than the untreated and among the patients with erythema nodosum leprosum than without. The results, therefore, suggest that anti-neural antibodies are elicited during the course of leprosy and may be associated with the extensiveness of nerve involvement in the patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-1186409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-2319183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-2463996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-2545801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-2674306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-3511085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-5950347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-6095579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-6190769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-6273673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-6323330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1544221-7028212
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
368-72
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1544221-Animals,
pubmed-meshheading:1544221-Antigen-Antibody Reactions,
pubmed-meshheading:1544221-Autoantibodies,
pubmed-meshheading:1544221-Blotting, Western,
pubmed-meshheading:1544221-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1544221-Humans,
pubmed-meshheading:1544221-Immunoglobulin G,
pubmed-meshheading:1544221-Intermediate Filaments,
pubmed-meshheading:1544221-Leprosy, Lepromatous,
pubmed-meshheading:1544221-Leprosy, Tuberculoid,
pubmed-meshheading:1544221-Rabbits,
pubmed-meshheading:1544221-Spinal Cord,
pubmed-meshheading:1544221-Tuberculosis, Meningeal
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pubmed:year |
1992
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pubmed:articleTitle |
Detection of antibodies to human nerve antigens in sera from leprosy patients by ELISA.
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pubmed:affiliation |
Department of Microbiology, Yonsei University College of Medicine, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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