Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5050
pubmed:dateCreated
1992-4-8
pubmed:abstractText
Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are multifunctional cytokines with many similar activities. LIF is structurally and functionally related to another cytokine, Oncostatin M (OSM), that binds to the high-affinity LIF receptor but not to the low-affinity LIF receptor. A complementary DNA was isolated that encodes the high-affinity converting subunit of the LIF receptor. The converter conferred high-affinity binding of both LIF and OSM when expressed with the low-affinity LIF receptor and is identical to the signal transducing subunit of the IL-6 receptor, gp130. The gp130 subunit alone confers low-affinity binding of OSM when expressed in COS-7 cells. This receptor system resembles the high-affinity receptors for granulocyte-macrophage colony-stimulating factor, IL-3, and IL-5, which share a common subunit.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD, http://linkedlifedata.com/resource/pubmed/chemical/Cytokine Receptor gp130, http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/Leukemia Inhibitory Factor, http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Oncostatin M, http://linkedlifedata.com/resource/pubmed/chemical/Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OSM-LIF, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
255
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
1434-7
pubmed:dateRevised
2007-3-19
pubmed:meshHeading
pubmed-meshheading:1542794-Animals, pubmed-meshheading:1542794-Antigens, CD, pubmed-meshheading:1542794-Binding, Competitive, pubmed-meshheading:1542794-Cell Line, Transformed, pubmed-meshheading:1542794-Cytokine Receptor gp130, pubmed-meshheading:1542794-Growth Inhibitors, pubmed-meshheading:1542794-Interleukin-6, pubmed-meshheading:1542794-Leukemia Inhibitory Factor, pubmed-meshheading:1542794-Lymphokines, pubmed-meshheading:1542794-Membrane Glycoproteins, pubmed-meshheading:1542794-Oncostatin M, pubmed-meshheading:1542794-Peptides, pubmed-meshheading:1542794-Radioligand Assay, pubmed-meshheading:1542794-Receptors, Cytokine, pubmed-meshheading:1542794-Receptors, Immunologic, pubmed-meshheading:1542794-Receptors, OSM-LIF, pubmed-meshheading:1542794-Recombinant Proteins, pubmed-meshheading:1542794-Transfection
pubmed:year
1992
pubmed:articleTitle
The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor.
pubmed:affiliation
Immunex Research and Development Corporation, Seattle, WA 98101.
pubmed:publicationType
Journal Article