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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1992-4-7
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pubmed:abstractText |
Molecular cloning of the polypeptide component of the Rel-related human p75 nucleoprotein complex has revealed its identity with the 65-kDa (p65) subunit of NF-kappa B. Functional analyses of chimeric proteins composed of NF-kappa B p65 C-terminal sequences linked to the DNA-binding domain of the yeast GAL4 polypeptide have indicated that the final 101 amino acids of NF-kappa B p65 comprise a potent transcriptional activation domain. Transient transfection of human T cells with an expression vector encoding NF-kappa B p65, but not NF-kappa B p50, produced marked transcriptional activation of a basal promoter containing duplicated kappa B enhancer motifs from the long terminal repeat of type 1 human immunodeficiency virus. These stimulatory effects of NF-kappa B p65 were synergistically enhanced by coexpression of NF-kappa B p50 but were completely inhibited by coexpression of the v-rel oncogene product. Together, these functional studies demonstrate that NF-kappa B p65 is a transactivating subunit of the heterodimeric NF-kappa B complex and serves as one cellular target for v-Rel-mediated transcriptional repression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-1903456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2001591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2006423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2023921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2040012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2111443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2125960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2157987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2203531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2203532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2203533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2204816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2225078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2263603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2357375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2494664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2518691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2557547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2665943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2666912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2691328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2785134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2836068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2838755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2838905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2843425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2843985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-2990028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-3028647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-3029959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-3037497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-3047590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-3091258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-3096580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-3129195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-3140380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-3681984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-3685975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-3907859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-4009718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-6090694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-6232133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-6258458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1542686-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:geneSymbol |
v-rel
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1875-9
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1542686-Humans,
pubmed-meshheading:1542686-Molecular Weight,
pubmed-meshheading:1542686-Base Sequence,
pubmed-meshheading:1542686-Amino Acid Sequence,
pubmed-meshheading:1542686-Macromolecular Substances,
pubmed-meshheading:1542686-Molecular Sequence Data,
pubmed-meshheading:1542686-Transcription, Genetic,
pubmed-meshheading:1542686-Cloning, Molecular,
pubmed-meshheading:1542686-Repressor Proteins,
pubmed-meshheading:1542686-Gene Expression Regulation,
pubmed-meshheading:1542686-Oligodeoxyribonucleotides,
pubmed-meshheading:1542686-Transcription Factors,
pubmed-meshheading:1542686-Retroviridae Proteins, Oncogenic,
pubmed-meshheading:1542686-Trans-Activators,
pubmed-meshheading:1542686-Enhancer Elements, Genetic
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