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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1992-4-6
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pubmed:abstractText |
Thirty-seven patients with spasmodic torticollis (cervical dystonia) who received repeated local injections of botulinum toxin have been followed up for a mean period of 12.3 (10-29) months, during which time 138 treatment sessions were performed. Mean doses per muscle averaged 320 mouse units (mu; range 160-1000 mu botulinum toxin A prepared by CAMR, Porton Down, UK). Eighty-six per cent of patients experienced significant improvement of posture and 84% of those with pain had relief following the first injection. Muscular patterns of recurrent torticollis were relatively constant and in most patients efficacy was maintained with subsequent injections, while 15% of all follow-up sessions failed. Only 2 of 37 patients were consistent nonresponders; 22% and 10% of all sessions were complicated by transient dysphagia and weakness of neck muscles, respectively. It is concluded that local botulinum toxin injections can be a safe and efficaceous long-term treatment of spasmodic torticollis and that optimal doses should be between 200 and 400 mu/muscle.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0340-5354
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
239
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1541964-Botulinum Toxins,
pubmed-meshheading:1541964-Deglutition Disorders,
pubmed-meshheading:1541964-Electromyography,
pubmed-meshheading:1541964-Female,
pubmed-meshheading:1541964-Follow-Up Studies,
pubmed-meshheading:1541964-Humans,
pubmed-meshheading:1541964-Injections, Intramuscular,
pubmed-meshheading:1541964-Male,
pubmed-meshheading:1541964-Torticollis
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pubmed:year |
1992
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pubmed:articleTitle |
Treatment of spasmodic torticollis with local injections of botulinum toxin. One-year follow-up in 37 patients.
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pubmed:affiliation |
Universitäts-Klinik für Neurologie, Innsbruck, Austria.
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pubmed:publicationType |
Journal Article,
Clinical Trial
|