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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-4-9
|
| pubmed:abstractText |
Actin, one of the most abundant proteins of the cell, is hydrolyzed by the human immunodeficiency virus type 1 (HIV-1) protease during acute infection of cultured human T lymphocytes. The actin fragments produced during the course of infection are identical to those obtained by recombinant HIV-1 protease digests of (1) a lysate from uninfected T lymphocytes and (2) globular actin itself. Hydrolysis by the HIV-1 protease of physiologically important host cellular proteins during infection may have important consequences relative to viral pathogenesis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0889-2229
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
291-5
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1540415-Actins,
pubmed-meshheading:1540415-Cell Line,
pubmed-meshheading:1540415-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:1540415-HIV Protease,
pubmed-meshheading:1540415-HIV-1,
pubmed-meshheading:1540415-Humans,
pubmed-meshheading:1540415-Hydrolysis,
pubmed-meshheading:1540415-T-Lymphocytes
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
HIV-1 protease cleaves actin during acute infection of human T-lymphocytes.
|
| pubmed:affiliation |
Biochemistry Unit, Upjohn Laboratories, Kalamazoo, MI 49001.
|
| pubmed:publicationType |
Journal Article
|