Source:http://linkedlifedata.com/resource/pubmed/id/15390175
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2004-12-6
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| pubmed:abstractText |
Synaptotagmin IV (Syt IV) is an activity-inducible, secretory vesicle protein that is thought to function as an inhibitor of neurotransmitter release (Littleton et al. Nature 400:757-760, 1999). To test this hypothesis in neurons of the mammalian CNS, we measured field excitatory postsynaptic potentials (fEPSPs) in hippocampal slice preparations from Syt IV (-/-) mice. At Schaffer collateral synapses, the basal properties of neurotransmission are largely normal. However, two forms of short-term plasticity, paired-pulse facilitation (PPF) and post-tetanic potentiation (PTP), are significantly enhanced in area CA1 of Syt IV (-/-) slices. Similarly, the early stages of long-term potentiation (LTP) are also enhanced at these synapses. Consistent with the low levels of Syt IV observed in dentate granule cells, the mossy fiber synapses in Syt IV (-/-) slices display largely normal PPF and LTP. In addition, we find that Syt IV (-/-) mice have deficits in the associative passive avoidance memory paradigm, but are normal in the novel object recognition paradigm. The synaptic architecture and connectivity of Syt IV (-/-) brains is indistinguishable from wild-type mice as indicated by immunohistochemical analysis. These results suggest Syt IV is a presynaptic negative regulator of short-term plasticity in area CA1 of the hippocampus and is required for some, but not all, forms of hippocampus-dependent memory.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Synaptotagmins,
http://linkedlifedata.com/resource/pubmed/chemical/Syt4 protein, mouse
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1050-9631
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| pubmed:author | |
| pubmed:copyrightInfo |
2004 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
964-74
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15390175-Animals,
pubmed-meshheading:15390175-Association Learning,
pubmed-meshheading:15390175-Avoidance Learning,
pubmed-meshheading:15390175-Calcium-Binding Proteins,
pubmed-meshheading:15390175-Dentate Gyrus,
pubmed-meshheading:15390175-Electric Stimulation,
pubmed-meshheading:15390175-Excitatory Postsynaptic Potentials,
pubmed-meshheading:15390175-Hippocampus,
pubmed-meshheading:15390175-Long-Term Potentiation,
pubmed-meshheading:15390175-Membrane Glycoproteins,
pubmed-meshheading:15390175-Memory, Short-Term,
pubmed-meshheading:15390175-Memory Disorders,
pubmed-meshheading:15390175-Mice,
pubmed-meshheading:15390175-Mice, Inbred C57BL,
pubmed-meshheading:15390175-Mice, Knockout,
pubmed-meshheading:15390175-Mossy Fibers, Hippocampal,
pubmed-meshheading:15390175-Nerve Tissue Proteins,
pubmed-meshheading:15390175-Neuronal Plasticity,
pubmed-meshheading:15390175-Organ Culture Techniques,
pubmed-meshheading:15390175-Presynaptic Terminals,
pubmed-meshheading:15390175-Synaptic Transmission,
pubmed-meshheading:15390175-Synaptotagmins
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| pubmed:year |
2004
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| pubmed:articleTitle |
Altered hippocampal short-term plasticity and associative memory in synaptotagmin IV (-/-) mice.
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| pubmed:affiliation |
Department of Pharmacology, Box 357750, Health Sciences Building, University of Washington, Seattle, Washington 98195, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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